INTERNATIONAL ARCHIVES OF MEDICINE SECTION: DERMATOLOGY ISSN: 1755-7682 International Medical Society http://imedicalsociety.org 1 2017 Vol. 10 No. 178 doi: 10.3823/2448 © Under License of Creative Commons Attribution 3.0 License This article is available at: www.intarchmed.com and www.medbrary.com Abstract Background: The etiopathogenesis of uremic pruritus (UP) is mul- tifactorial aspect, and it is thus necessary to elucidate its associated factors to develop efficient therapeutics approaches. This study aimed to verify the prevalence of UP and its associated factors. Methods and Findings: Prospective and cross-sectional study with patients undergoing hemodialysis at a university public hospital. The data were obtained between April 2014 and April 2015. The statisti- cal analysis was carried out using multivariate regression models, and statistical significance was set at p<0.05. A total of 164 patients were included, and pruritus was reported in 64 (39%). In the multivariate analysis, a higher creatinine level was risk factor for pruritus (β=1.09, 95% CI 1.00-1.19; p=0.048), as was a lower level of hemoglobin (β=0.85, 95% CI 0.73-0.99; p=0.043). Dyslipidemia (β=1.52, 95% CI 0.12-2.91; p=0.03), obesity (β=2.40, 95% CI 1.03-3.78; p=0.001), hig- her levels of C-reactive protein (β=0.26, 95% CI 0.19-0.34; p<0.001) and black race (β=1.49, 95% CI -2.57 and 0.42; p<0.006) were as- sociated with a greater intensity of pruritus. The use of a high-flux dialyzer was associated with a lower intensity of pruritus (β=-1.69, 95% CI -3.05-0.34; p=0.01). Conclusion: Uremic pruritus has a high prevalence in hemodialysis patients, and the data suggest that the higher the creatinine and the lower the hemoglobin levels are, the greater the risk of developing pruritus is. Dyslipidemia, obesity, and higher levels of C-reactive protein were associated with a greater intensity of pruritus, whereas the use of a high-flux dialyzer was associated with lower pruritus intensity. Factors Associated with Uremic Pruritus ORIGINAL Mariele Gobo-Oliveira 1 , Vitória G. Pigari 2 , Matheus S.P. Ogata 2 , Hélio A. Miot 2 , Daniela Ponce 3 , Luciana P.F. Abbade 2 1 Department of Nursing, Dialysis Unit, Botucatu Medical School, São Paulo State University (UNESP). 2 Department of Dermatology and Radiotherapy, Botucatu Medical School, São Paulo State University (UNESP). 3 Department of Medical Clinic, Nephrology, Botucatu Medical School, São Paulo State University (UNESP). Contact information: Luciana Patrícia Fernandes Abbade. Address: Campus Universitário de Rubião Jr. CEP: 18618-970. Botucatu, SP, Brasil. Tel: +55(14) 38801259.  lfabbade@fmb.unesp.br Keywords Cutaneous Manifestations of Systemic Disease; General Dermatology; Internal Disease Associated with Dermatology. Introduction Uremic pruritus (UP) is one of the most common symptoms observed in patients with stage 5D chronic kidney disease (CKD). Its prevalence