1 COVID-19 Prognostic Modeling Using CT 1 Radiomic Features and Machine Learning 2 Algorithms: Analysis of a Multi-Institutional 3 Dataset of 14,339 Patients 4 Isaac Shiri 1 , Yazdan Salimi 1 , Masoumeh Pakbin 2 , Ghasem Hajianfar 3 , Atlas Haddadi Avval 4 , Amirhossein Sanaat 1 , 5 Shayan Mostafaei 5,6 , Azadeh Akhavanallaf 1 , Abdollah Saberi 1 , Zahra Mansouri 1,7 , Dariush Askari 8 , 6 Mohammadreza Ghasemian 9 , Ehsan Sharifipour 10 , Saleh Sandoughdaran 11 , Ahmad Sohrabi 12 , Elham Sadati 13 , 7 Somayeh Livani 14 , Pooya Iranpour 15 , Shahriar Kolahi 16 , Maziar Khateri 17 , Salar Bijari 13 , Mohammad Reza 8 Atashzar 18 , Sajad P. Shayesteh 19 , Bardia Khosravi 35 , Mohammad Reza Babaei 20 , Elnaz Jenabi 21 , Mohammad 9 Hasanian 22 , Alireza Shahhamzeh 23 , Seyed Yaser Foroghi Gholami 23 , Abolfazl Mozafari 24 , Arash Teimouri 15 , 10 Fatemeh Movaseghi 24 , Azin Ahmari 25 , Neda Goharpey 26 , Rama Bozorgmehr 27 , Hesamaddin Shirzad-Aski 28 , 11 Rozbeh Mortazavi 29 , Jalal Karimi 30 , Nazanin Mortazavi 31 , Sima Besharat 32 , Mandana Afsharpad 12 , Hamid 12 Abdollahi 33 , Parham Geramifar 34 , Amir Reza Radmard 35 , Hossein Arabi 1 , Kiara Rezaei-Kalantari 3 , Mehrdad 13 Oveisi 36 , Arman Rahmim 37,38 & Habib Zaidi 1,39,40,41 14 1. Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, 1211, 15 Switzerland 16 2. Imaging Department, Qom University Of Medical Sciences, Qum, Iran 17 3. Rajaie Cardiovascular, Medical & Research Center, Iran University of Medical Science, Tehran, 18 Iran 19 4. School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 20 5. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, 21 Karolinska Institute, Stockholm, Sweden 22 6. Department of Biostatistics, Kermanshah University of Medical Sciences, Kermanshah, Iran 23 7. Department of Biomedical engineering and medical physics, Shahid Beheshti University of 24 Medical Sciences, Tehran, Iran 25 8. Department of Radiology Technology, Shahid Beheshti University of Medical Sciences, Tehran, 26 Iran 27 9. Department of Radiology, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qum, 28 Iran 29 10. Neuroscience Research Center, Qom University of Medical Sciences, Qum, Iran 30 11. Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical 31 Sciences, Tehran, Iran 32 12. Cancer control research center, cancer control foundation, Iran University of medical sciences, 33 Tehran, Iran 34 13. Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 35 Iran 36 14. Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of 37 Medical Sciences, Gorgan, Iran 38 15. Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical 39 Sciences, Shiraz, Iran 40 16. Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology 41 Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, 42 Tehran, Iran 43 44 . CC-BY-NC-ND 4.0 International license It is made available under a perpetuity. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted December 7, 2021. ; https://doi.org/10.1101/2021.12.07.21267364 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.