REVIEW ARTICLE Department of Pharmacy Rajesh et.al / UJPSR / 3 (1), 2017, 24-33 e ISSN: 2454-3764 Print ISSN: 2454-3756 DOI: 10.21276/UJPSR.2017.03.01.99 24 | Page A REVIEW ON CUBOSOME AND VIROSOME: THE NOVEL DRUG DELIVERY SYSTEM Rajesh Sen*, Radhika Gupta, Simran Singh, Shubhrajit Mantry, Sudip Das Department of Pharmacy, Himalayan Pharmacy Institute, Majhitar, Sikkim, INDIA ARTICLE INFO: Article history: Received: 1 th March 2017 Received in revised form: 13 th April 2017 Accepted: 7 th May 2017 Available online: 10 th June 2017 Corresponding Author: Rajesh Sen Himalayan Pharmacy Institute Majhitar, Sikkim, 737136, INDIA Email: rajeshsen00786@gmail.com Phone: +91-8927481594 Abstract Cubosomes are square and rounded particles with internal cubic lattices visible. The invention of cubosomes is a distinctive story and spans the fields of food science, differential geometry, biological membranes and digestive processes. Cubosomes are thermodynamically stable; they have a structure like “honeycombed” with bicontinuous domains of water and lipid in which surfactant assembles into bilayers and twisted into a three dimension, periodic, and minimal surface, forming a tightly packed structure. Virosomes are reconstituted viral envelopes that can serve as vehicles for cellular delivery of macromolecules. The prospect of drug delivery and targeting using virosomes is an interesting field of research and development. Because virosomes are biocompatible, biodegradable, nontoxic and non- autoimmunogenic. These are reconstituted viral envelopes that can serve as vehicles for cellular delivery of macromolecules. The prospect of drug delivery and targeting using virosomes is an interesting field of research and development. Key words Virosome, Cubosome, Novel drug delivery, Cancer diagnosis INTRODUCTION The aim of drug delivery system is to deliver the drug based on the needs of the body. To achieve controlled and targeted drug delivery by encapsulating the drug within vesicular structure such a system is known to be vesicular drug delivery system. In this system if the vesicles behave as carrier system will transport high molecular weight of drugs, and if behave as penetration enhancer will increasing the drug transport rate across the skin. There is huge number of vesicular drug delivery systems were developed that allow drug targeting and the sustained or controlled release of conventional medicines. In such a system cubosomes are also part of the vesicular drug delivery system or lipid based colloidal system which were discovered in 1980 [1]. Virosomes are reconstituted viral envelopes that can serve as vaccines and as vehicles for cellular delivery of macromolecules. virosomes are biocompatible, biodegradable, nontoxic, and non autoimmunogenic, attempts have been made to use them as vaccines or adjuvants as well as delivery systems for drugs, nucleic acids, or genes for therapeutic purposes. Influenza virus is the most common virus of choice [2].