REVIEW OF INTERNATIONAL GEOGRAPHICAL EDUCATION ISSN: 2146-0353 ● © RIGEO ● 11(7), SPRING, 2021 www.rigeo.org Research Article Immune System Defense Mechanism K Ram Chandra 1 Professor and Head, Department of English, V R Siddhartha Engineering College (Autonomous)Vijayawada, A.P, India P Jyothi Kumari 2 Associate Professor, Department of Nutrition, Ch.S.D.St.Theresa's College for Women (A), Eluru, A.P, India V Sandhya 3 Lecturer, Department of Zoology, Ch VPMR Government Degree College, Ganapavaram, A.P, India R Indira 5 Associate Professor, Department of Zoology, Ch. S. D. St. Theresa's College for Women (A), Eluru, A.P, India Srivastava Pratima Kumari 4 Associate Professor, Department of Zoology, Ch. S. D. St. Theresa's College for Women (A), Eluru, A.P, India K S V K S Madhavi Rani 6 Associate Professor, Department of Zoology, Ch. S. D. St. Theresa's College for Women (A), Eluru, A.P, India Corresponding author: Professor and Head, Department of English, V R Siddhartha Engineering College (Autonomous)Vijayawada, A.P, India Email: Not given Abstract Singular living beings live respectively in an environment and rely upon each other. Albeit large numbers of these are kind, not all are, and everything alive commits critical assets to recognize and killing dangers from different species. Essentially all living beings have some sort of resistant framework. Microbes have a simple insusceptible framework as compounds that ensure against infection contaminations. Gnathostomata, including people, have significantly more complex safeguard instruments, including the capacity to adjust to perceive microbes all the more productively. This paper centres around mammalian insusceptibility, the difficulties that it faces, the systems by which these are tended to, and the results that emerge when it breakdowns. Also, a brief discussion of how vaccines are helping in providing immune attacks against microorganisms is briefly discussed. Keywords Microorganisms, Innate Immunity, Adaptive Immunity, Antibody, Antigen, Vaccine, Herd Immunity To cite this article: Chandra, K, R.; Kumari, P, J.; Sandhya, V.; Kumari, S, P.; Indira, R.; and Rani, K, S, V, K, S, M. (2021) Immune System Defense Mechanism. Review of International Geographical Education (RIGEO), 11(7), 461-472. doi: 10.48047/rigeo. 11.07.50 Submitted: 03-10-2020 ● Revised: 05-12-2020 ● Accepted: 07-02-2021