                   Shanshan Liu 1 , Yu Sun 1 , Ming Jiang 2 , Yangkai Li 3 , Ye Tian 1 , Weili Xue 1 , Ninghe Ding 2 , Yue Sun 1 , Cheng Cheng 2 , Jianshuang Li 1 , Xiaoping Miao 4 , Xinran Liu 2 , Ling Zheng 1 * and Kun Huang 2 * 1 Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, P. R. China, 430072 2 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 430030 3 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 430030 4 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 430030 Corresponding authors Ling Zheng, Ph.D. Kun Huang, Ph.D. College of Life Sciences Tongji School of Pharmacy Wuhan University Huazhong Univ. of Sci. and Tech. Wuhan, China 430072 Wuhan, China, 430030 lzheng@whu.edu.cn kunhuang@hust.edu.cn This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/hep.29202 This article is protected by copyright. All rights reserved.