Pharmacologyonline 1: 15-21 (2011) Murti et al. 15 ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF ROOTS OF BOERHAAVIA DIFFUSA ON STREPTOZOTOCIN INDUCED DIABETIC RATS Krishna Murti 1 *, Vijay Lambole 2 , Mayank Panchal 2 , Upendra Kumar 3 1* Dept. of Pharmacology, Dr.K.N.Modi Institute of Pharmaceutical Education & Research Centre, Modinagar, India 2 Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India 3 Upendra Kumar, Azamgarh College of Pharmacy, Azamgarh (U.P,India) Correspondence Author: * Krishna Murti Email: krishnamurti74@yahoo.co.in Contact: +91-9328832853 Summary . . The present study was aimed to evaluate the anti diabetic - activity potential of Boerhaavia Diffusa roots against streptozotocin (STZ) induced experimental rats. Ethanolic extract of roots of Boerhaavia Diffusa was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Boerhaavia Diffusa (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Boerhaavia Diffusa (400 mg/kg). An ethanolic extract of Boerhaavia Diffusa was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Boerhaavia Diffusa on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Boerhaavia Diffusa possesses a hypoglycemic and antihyperlipidemic effect. Key words: Boerhaavia Diffusa • Glibenclamide • Hypoglycemia • Antihyperlipidemic • Streptozotocin