1 A multimodal Mass Spectrometry Imaging approach for the study of musculoskeletal tissues Sanaullah Chughtai 1 , Kamila Chughtai 1 , Berta Cillero Pastor 1 , András Kiss 1,3 , Prashant Agrawal 2,§ , Luke MacAleese 1,* , Ron M.A. Heeren 1,3 1 FOM-Institute AMOLF, Science Park 104, 1098 XG Amsterdam The Netherlands 2 Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands 3 The Netherlands Proteomics Centre, H.R. Kruytgebouw, East 6.11 Padualaan 8, 3584 CH Utrecht, The Netherlands § Current Address: Ira Agrotech and Research Pvt Ltd, B 1/2, MIDC, Butibori, Nagpur, (MS) India - 440015 * Current Address: Université Claude Bernard Lyon 1, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne cedex, France Email addresses: Sanaullah Chughtai: chughtai@amolf.nl Kamila Chughtai: czornak@amolf.nl Berta Cillero Pastor: cillero@amolf.nl András Kiss: kiss@amolf.nl Prashant Agrawal: aprashantr@gmail.com Luke MacAleese: luke.macaleese@lasim.univ-lyon1.fr Corresponding author Ron M.A. Heeren: r.heeren@amolf.nl Tel. +31-20-7547100 Fax. +31-20-7547290