Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jpi.12506 This article is protected by copyright. All rights reserved. DR MARIA J TUÑON (Orcid ID : 0000-0001-7827-5918) Article type : Original Manuscript Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma Diana I Sánchez 1 , Bárbara González-Fernández 1 , Irene Crespo 1,2 , Beatriz San-Miguel 1 , Marcelino Álvarez 3 , Javier González-Gallego 1,2* and María Jesús Tuñón 1,2* 1 Institute of Biomedicine (IBIOMED), University of León, León, Spain. 2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain. 3 Department of Animal Health, University of León, León, Spain. *JGG and MJT share senior authorship Running head: Circadian clock genes and melatonin in hepatocarcinoma Address reprint requests to María J. Tuñón, PhD, Institute of Biomedicine, University of León, 24071-León, Spain. Phone: +34 987 291261; Fax: +34 987 291267. E-mail: mjtung@unileon.es