to intellectual activity was restored, but reduced its productivity. For the study of social support we evaluated relationship of patients with the relatives and friends. They were estimated as well in only 24.8% of the patients, in 24.6% of cases there were conflicts, ten- sions, in 34.8% - unstable and 15.8% - neutral relationship. Psycho- social problems in families of patients can be considered, along with issues of working adaptation, as complicating the disease and reducing the quality of life of patients. Conclusions: As part of physical functioning, deterioration of life of the individual caused by problems of physical pain or physical discomfort, fatigue and lack of energy and strength, as well as the inability to sufficiently relax. The difficulties in the psychological field, adversely affecting the well-being of life, arose due to the lack of positive or negative emotions excess, problems with thinking, memory and attention, as well as due to lower self-esteem. The results obtained in the study relating to the functioning of patients, along with clinical character- istics may be one of the most important components of evaluation of the quality of mental health care, used in the planning of activ- ities of mental health services, to carry out more targeted medical and social assistance. P4-180 THE RATIONALE AND PROTOCOL FOR THE SYSTEMATIC MULTIDOMAIN ALZHEIMER’S RISK REDUCTION TRIAL (SMARRT) Kristine Yaffe 1,2 , Dori E. Rosenberg 3 , Evette Ludman 3 , Deborah E. Barnes 1,2 , Sascha Dublin 3 , Allison R. Kaup 1,2 , Eric Vittinghoff 1 , Eric B. Larson 3 , 1 University of California, San Francisco, San Francisco, CA, USA; 2 San Francisco VA Health Care System, San Francisco, CA, USA; 3 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. Contact e-mail: kristine.yaffe@ucsf.edu Background: Alzheimer’s disease (AD) prevalence is expected to triple by 2050, and current medications do not change the disease course. Recent studies have projected that up to 30% of AD and other dementias may be preventable by targeting modifiable risk factors. Yet, multi-domain interventions aimed at reducing risk fac- tors for dementia have not been well studied (especially in the US) and rarely with a personalized approach. We present the protocol for a new NIH-funded pilot trial designed to assess the effect of personalized risk factor modification on 2-year cognitive decline among members of an integrated health care delivery system. Methods: The Systematic Multidomain Alzheimer’s Risk Reduction Trial (SMARRT) is a 2-year pilot trial designed to compare a personalized risk reduction intervention to usual care among 200 at risk older adults without dementia. Intervention participants will receive a personalized team-based (e.g. health coach, nurse) program with contacts by phone and in person. Key components are tailored risk assessments, personalized action plans, and content addressing various risk factors including poor hypertension and diabetes control; smoking; physical inactivity; depression; social isolation; diet; poor sleep quality and high risk medications. The control group will receive health education materials over the 2- year period. Results: We have developed a novel personalized multi-domain risk reduction intervention to reduce AD risk and slow cognitive decline in an integrated healthcare delivery setting. An in-depth protocol has been developed to conduct this novel trial. An operations manual and intervention modules have been de- signed, and a DSMB has been convened. The primary outcome of the trial will be cognitive test performance; secondary outcomes will include risk reduction, quality of life, functional status, and incident mild cognitive impairment. Conclusions: The results will provide insight into key dementia risk reduction strategies and their effects on cognitive decline among older adults at increased risk for dementia and lay the groundwork for large scale roll-out of this intervention. P4-181 QUANTIFYING INTERACTIONS BETWEEN GAZE BEHAVIOR AND PHYSIOLOGICAL RESPONSES WHEN VIEWING JAPANESE STYLE GARDENS Congcong Liu 1 , Yawen Zhang 2 , Seiko Goto 3 , Minkai Sun 4 , Karl Herrup 1 , Bertram Shi 5 , 1 Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong; 2 Hong Kong University of Science and Technolgy, Clear Water Bay, Kowloon, Hong Kong; 3 Department of Environmental Studies, Nagasaki University, Nagasaki, Japan; 4 Department of Environmental Studies, Nagasaki University, Nagasaki, Japan; 5 Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong. Contact e-mail: herrup@ust.hk Background: Many non-pharmacological interventions are useful in the treatment of Alzheimer disease (AD) – horticulture therapy, cognitive therapy, behavioral therapy, naturalistic approaches. The goal is to provide a well-structured environment to sustain optimal functioning for persons with dementia. Previous research has shown that such persons respond positively to viewing Japanese garden, but it was not clear which visual aspects of the garden were responsible, nor how subjects’ visual interaction with the scene affected their responses. Methods: We developed a system to collect synchronized measurements of eye gaze and three physiological in- dicators of sympathetic neural activity, electrocardiogram, blood volume pulse and galvanic skin response, as subjects view an out- door scene. Eye gaze is collected non-intrusively using a Tobii Pro X60 remote eye tracker. Physiological signals were measured by a Thought Technology ProComp Infiniti system via sensors attached to one hand. Specialized hardware ensures synchronization be- tween the two systems. All four measures are non-invasive and do not introduce excessive stress. We tested both young and elderly persons and measured the impact of a traditional Japanese garden design. Results: The majority of the young responded more posi- tively to the well-constructed garden than to an unstructured space. Ambient temperature proved to be a factor in our repeated experi- ments; heart rate and sympathetic activity increased in lower tem- peratures. We characterized the rate at which subjects changed their gaze target using average fixation duration and gaze transition en- tropy. Longer fixations and lower transition entropy suggest higher engagement with particular elements in the visual environment. In the garden environment, mean fixation duration was longer and both transition entropy and mean HR were lower. Gaze transition entropy and mean HR were positively correlated. In a pilot test of our system on elderly individuals, the measuring devices were well tolerated and a rich data set was generated. Conclusions: Our initial result confirms that subjects respond positively to the garden environment, and that this effect depends upon the way the subjects visually engage with it. Subjects are more engaged and relaxed in the garden. More engagement leads to more relaxation. Addition- ally, the impact of ambient temperature cannot be neglected. P4-182 A STUDY ON THE CARE NEEDS OF MICRO-ORGANIZATION IN THE COMMUNITY OLD PEOPLE IN NINGBO CITY Ning Sun, Ningbo Health Scientific College, Ningbo, China. Contact e-mail: sunning_ly@126.com Poster Presentations: July 25, 2018 P1508