How stressful are 105 days of isolation? Sleep EEG patterns and tonic cortisol in healthy volunteers simulating manned flight to Mars Angelo Gemignani, Andrea Piarulli, Danilo Menicucci, Marco Laurino, Giuseppina Rota, Francesca Mastorci, Vadim Gushin, Olga Shevchenko, Erika Garbella, Alessandro Pingitore, Laura Sebastiani, Massimo Bergam- asco, Antonio L’Abbate, Paolo Allegrini, Remo Bedini PII: S0167-8760(14)00108-1 DOI: doi: 10.1016/j.ijpsycho.2014.04.008 Reference: INTPSY 10790 To appear in: International Journal of Psychophysiology Received date: 30 November 2013 Revised date: 5 April 2014 Accepted date: 24 April 2014 Please cite this article as: Gemignani, Angelo, Piarulli, Andrea, Menicucci, Danilo, Laurino, Marco, Rota, Giuseppina, Mastorci, Francesca, Gushin, Vadim, Shevchenko, Olga, Garbella, Erika, Pingitore, Alessandro, Sebastiani, Laura, Bergamasco, Mas- simo, L’Abbate, Antonio, Allegrini, Paolo, Bedini, Remo, How stressful are 105 days of isolation? Sleep EEG patterns and tonic cortisol in healthy volunteers simu- lating manned flight to Mars, International Journal of Psychophysiology (2014), doi: 10.1016/j.ijpsycho.2014.04.008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.