Accepted Manuscript Title: In vitro and in vivo investigation of metabolic fate of Riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET Predictor TM Authors: Shristy S. Tiwari, Balasaheb B. Chavan, Bhoopendra S. Kushwah, Naga Veera Yerra, Sumit Mukesh, Abhay T. Sangamwar, Jagadeshwar Reddy Thota, M.V.N. Kumar Talluri PII: S0731-7085(18)31963-0 DOI: https://doi.org/10.1016/j.jpba.2018.10.050 Reference: PBA 12300 To appear in: Journal of Pharmaceutical and Biomedical Analysis Received date: 28 August 2018 Revised date: 25 October 2018 Accepted date: 28 October 2018 Please cite this article as: Tiwari SS, Chavan BB, Kushwah BS, Veera Yerra N, Mukesh S, Sangamwar AT, Reddy Thota J, Kumar Talluri MVN, In vitro and in vivo investigation of metabolic fate of Riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET Predictor TM , Journal of Pharmaceutical and Biomedical Analysis (2018), https://doi.org/10.1016/j.jpba.2018.10.050 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.