Accepted Manuscript Title: In vitro antitumor and antiangiogenic effects of Bothropoidin, a metalloproteinase from Bothrops pauloensis snake venom Authors: Denise de Oliveira Guimar˜ aes, Daiana Silva Lopes, Fernanda VanPetten Vasconcelos Azevedo, Sarah Natalie Gimenes, Makswell Almeida Silva, David Collares Achˆ e, M´ ario S´ ergio Rocha Gomes, Lara Vecchi, Luiz Ricardo Goulart, Kelly Aparecida Geraldo Yoneyama, Renata Santos Rodrigues, Veridiana de Melo Rodrigues PII: S0141-8130(16)31364-2 DOI: http://dx.doi.org/doi:10.1016/j.ijbiomac.2017.01.064 Reference: BIOMAC 6971 To appear in: International Journal of Biological Macromolecules Received date: 30-8-2016 Revised date: 11-1-2017 Accepted date: 12-1-2017 Please cite this article as: Denise de Oliveira Guimar˜ aes, Daiana Silva Lopes, Fernanda Van Petten Vasconcelos Azevedo, Sarah Natalie Gimenes, Makswell Almeida Silva, David Collares Achˆ e, M´ ario S´ ergio Rocha Gomes, Lara Vecchi, Luiz Ricardo Goulart, Kelly Aparecida Geraldo Yoneyama, Renata Santos Rodrigues, Veridiana de Melo Rodrigues, In vitro antitumor and antiangiogenic effects of Bothropoidin, a metalloproteinase from Bothrops pauloensis snake venom, International Journal of Biological Macromolecules http://dx.doi.org/10.1016/j.ijbiomac.2017.01.064 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.