This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/bcpt.12108 This article is protected by copyright. All rights reserved. Received Date: 10-May-2013 Accepted Date: 28-Jun-2013 Article Type: Original Article Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Subjects Running Title: Increased oral bioavailability of loperamide by HM30181 Yu-Jung Cha 1,* , Howard Lee 2,* , Namyi Gu 1 , Tae-Eun Kim 1 , Kyoung Soo Lim 1 , Seo Hyun Yoon 1 , Jae-Yong Chung 1 , In-Jin Jang 1 , Sang-Goo Shin 1 , Kyung-Sang Yu 1 and Joo-Youn Cho 1 1 Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital 2 Clinical Trials Center, Seoul National University Hospital *These authors contributed equally to this work. (Received 10 May 2013; Accepted 28 June 2013)