International Journal of Research in Medical Sciences | February 2022 | Vol 10 | Issue 2 Page 470 International Journal of Research in Medical Sciences Mukhopadhyay B et al. Int J Res Med Sci. 2022 Feb;10(2):470-476 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article A unique study of post mitral valve surgery status of patients in pre and intra COVID-19 era Bhubandeep Mukhopadhyay*, P. Banerjee INTRODUCTION Functions of the right and left sided hearts are interrelated. Left sided heart diseases can affect the right heart and likewise right sided diseases can affect the normal functions of the left heart. Pulmonary artery hypertension results in right ventricular hypertrophy and right ventricular enlargement. When the pulmonary artery systolic pressure increases more, both right ventricular end-diastolic pressure and volume rise gradually, leading to right ventricular dilatation. This will be further complicated by the dilatation of the tricuspid valve annulus. The circumference of the annulus lengthens primarily along the attachments of the anterior and posterior leaflets. 1 The septal leaflet is fixed between the fibrous trigones, preventing lengthening. Dilation of the tricuspid annulus therefore occurs primarily in its anterior/posterior (mural) aspect, which can result in significant functional tricuspid regurgitation (TR) as a result of leaflet mal coaptation. Pulmonary arterial (PA) hypertension is a frequent and serious complication of mitral valve disease, and it is a major risk factor for poor outcome after surgery for mitral stenosis or mitral regurgitation. 2-5 Not surprisingly, the impact of PA Department of Cardiothoracic Vascular Surgery, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Received: 15 December 2021 Revised: 06 January 2022 Accepted: 11 January 2022 *Correspondence: Dr. Bhubandeep Mukhopadhyay, E-mail: bhubandeep@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: In this study we have studied the change of pulmonary artery pressure after mitral valve replacement and closed mitral commissurotomy. We have also correlated pulmonary artery pressure before and after operation with postoperative outcome. Methods: This study was conducted at Department of CTVS of NRS Medical College and Hospitals from August 2019 to September 2021. All 81 patients had rheumatic mitral valve disease. Among these 73 patients underwent mitral valve replacement (MVR) and 8 patients underwent closed mitral commissurotomy (CMC). Group 1 (n=35) consisted of patients who underwent MVR having preoperative systolic PAP measured by TTE was less than 50 mmHg. Group 2 patients (n=38) had preoperative systolic PAP more than or equal to 50 mmHg measured by TTE. Group 3 patients (n=8), consists of patients who underwent CMC. Compared the results between group 1 and 2 and documented the results of group 3 separately. Results: Our results showed a significant decrease in SPAP after MVR, and further fall of SPAP in the immediate and late postoperative period. Conclusions: In conclusion, PAP returns to near-normal values after MVR in patients with severe preoperative PAH and to normal values in patients with mild preoperative PAH. Reductions in PAP in patients with preoperative PAH occur immediately after MVR. Postoperative period of patients with severe PAH may be hectic. CMC may be a valid option in isolated MS in selected patients and is very much cost-effective. There were no differences noted among the types of valves used. Keywords: Hemodynamic, Mitral valve disease, Mitral valve replacement, Pulmonary hypertension DOI: https://dx.doi.org/10.18203/2320-6012.ijrms20220294