_____________________________________________________________________________________________________ *Corresponding author: E-mail: amankwah60@gmail.com, emmanuel.amankwah@uenr.edu.gh; Current Journal of Applied Science and Technology 39(44): 15-25, 2020; Article no.CJAST.62615 ISSN: 2457-1024 (Past name: British Journal of Applied Science & Technology, Past ISSN: 2231-0843, NLM ID: 101664541) Toxic Metal Contamination of Locally Produced Tobacco in Tamale Metropolis in Northern Region of Ghana G. E. Sebiawu 1 , N. J. Mensah 2 , E. Amankwah 3* and S. Antwi-Akomeah 4 1 Department of Dispensing Technology, Wa Technical University, Wa, Ghana. 2 Department of Science Laboratory Technology, Wa Technical University, Wa, Ghana. 3 Department of Mechanical and Manufacturing Engineering, UENR, Sunyani, Ghana. 4 Forensic Science Laboratory, Ghana Police Service, Accra, Ghana. Authors’ contributions This work was carried out in collaboration among all authors. Authors GES and SAA designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors NJM and EA managed the analyses and literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/CJAST/2020/v39i4431147 Editor(s): (1) Dr. David Morales-Morales, Universidad Nacional Autónoma de México, Mexico. Reviewers: (1) Rita Sundari, Universitas Mercu Buana, Indonesia. (2) Rodrigo Fernando dos Santos Salazar, Cruz Alta University, Brazil. Complete Peer review History: http://www.sdiarticle4.com/review-history/62615 Received 28 September 2020 Accepted 03 December 2020 Published 31 December 2020 ABSTRACT The study was to analyze and determine the toxic metal contamination level of locally produced tobacco sold in the Tamale Metropolis of Northern region. The study was carried out at the Tamale Metropolis of Northern region of Ghana within a period of 12 months. The study focused on the analyses of five (5) toxic metal contaminants in twelve (12) variant locally produced tobacco sold in various spots within the Tamale Metropolis of Ghana. Toxic metals including As, Cd, Hg, Pb and Cr were analyzed using Flame Atomic Absorption Spectrophotometer. The mean recorded concentrations of As, Cd, Hg, Pb and Cr were respectively in the ranges of 0.184 ± 0.011 to 0.515 ± 0.015 µg/kg, 0.0420 ± 0.010 to 3.100 ± 0.000 µg/kg, 0.176 ± 0.016 to 0.291 ± 0.009 µg/kg, 1.169 ± 0.019 to 3.195 ± 0.019 µg/kg and 1.600 ± 0.116 to 3.880 ± 0.369 µg/kg. The mean concentrations of As and Pb measured in all samples tested were below their respective WHO permissible limits of 4.00 ppm and 10.00 ppm. In the case of Cd, mean concentrations measured for all locally produced Original Research Article