This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/jlcr.3496 This article is protected by copyright. All rights reserved. cGMP Production of the Radiopharmaceutical [ 18 F]MK-6240 for PET imaging of Human Neurofibrillary Tangles Thomas Lee Collier, 1,2,3,† Daniel L. Yokell, 1,2† Eli Livni, 1,2 Peter A. Rice, 1 Sofie Celen, 4 Kim Serdons, 5 Ramesh Neelamegam, 1,2 Guy Bormans, 4 Dawn Harris 6 , Abbas Walji, 6 Eric D. Hostetler 6 Idriss Bennacef, 6 and Neil Vasdev 1,2,* † equal contribution 1. Division of Nuclear Medicine and Molecular Imaging, Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit St., White 427, Boston, Massachusetts, 02114, United States of America. 2. Department of Radiology, Harvard Medical School, 55 Fruit St., White 427, Boston, Massachusetts, 02114, United States of America. 3. Advion Inc., 10 Brown Road, Ithaca, New York, 14850, United States of America. 4. Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg O&N 2, Herestraat 49 bus 821, 3000, KU Leuven, Belgium. 5. Department of Nuclear Medicine, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium 6. Merck Research Laboratories, Merck & Co., West Point, Pennsylvania, 19486, United States of America. *Corresponding Author: Neil Vasdev, Ph.D. Director of Radiochemistry, Massachusetts General Hospital Associate Director, Gordon Center for Medical Imaging Associate Professor, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging 55 Fruit St., White 427 Boston, Massachusetts, 02114 Tel: 617-643-4736 E-mail: vasdev.neil@mgh.harvard.edu