P.2.e. Mood disorders and treatment − Treatment (basic) S451 schizophrenia. However, drug treatment of schizophrenia re- mains problematic; and the therapeutic effects of antipsychotic drugs in the different behavioral dimensions of schizophrenia are still largely unknown [2]. To address this question, an animal model of schizophrenia with prenatal neurogenesis disruption with methylazoxymethanol (MAM) was used. To induce this model, MAM was administrated in pregnant dams (Wistar rats prenatally treated at gestational day 17, 20 mg/kg) [3]. Schizophrenia-like phenotype was evaluated in the male offspring (3 months old) using the pre-pulse inhibition (PPI) test. These animals were subsequently treated (intraperitoneal injection) with the classic antipsychotic drug haloperidol (0.05 mg/kg/day), and three differ- ent atypical antipsychotics clozapine (2.5 mg/kg/day), risperidone (0.25 mg/kg/day) and aripiprazole (1 mg/kg/day) for a period of five weeks. During the last two weeks of treatment a battery of behavior tests to assess mood (forced swimming test (FST)), anxiety (elevated-plus maze test (EPM)), cognition (Morris water maze (MWM) and novel object recognition (NOR) test) and social interaction (three-chamber sociability test) were performed. After confirmation of homogeneity, appropriate statistical tests were applied to the data. Repeated measures ANOVA were used to analyze the MWM. Two-factor ANOVA was used to evaluate the remaining behavioral data. Differences between groups were then determined by Tukey’s honestly significant difference test (Tukey HSD) post hoc analysis. Statistical significance was accepted for P < 0.05. Our data indicates that animals exposed to MAM in utero present no alterations in the FST and EPM and also in the different tasks of the MWM. Regarding social interaction using the three chamber test, MAM animals present a decrease in the time spend interacting (time spent with another rodent). The classical antipsychotic drug haloperidol had no significant effects on sociability. The atypical antipsychotic drugs clozapine, risperidone and aripiprazole were able to revert the impairment on sociability induced by MAM exposure. Regarding cognition, animals exposed to MAM in the prenatal period reveal impairment in the novel object recognition task, spending less time explor- ing the novel object (revealing impairments in discrimination). The classical antipsychotic drug haloperidol had no significant cognitive effects in these animals. The atypical antipsychotic drugs clozapine and risperidone were able to revert the cognitive impairment induced by mam exposure. The effects of aripiprazole on cognition were not significant. In summary, using a neurodevel- opmental animal model of schizophrenia (MAM model) we iden- tify specific cognitive deficits and social interaction impairments that are differentially modulated by different antipsychotic drugs. The classical haloperidol presents no beneficial effects in these behavior dimensions. On the other hand, the atypical clozapine and risperidone have a positive effect on both dimensions with aripiprazole presenting only a significant effect in the social measure References [1] Os, J.V., 2009. Clinical overview “Salience syndrome” replaces schizo- phrenia in DSM-V and ICD-11 : psychiatrys evidence-based entry into the 21st century ? Acta Psychiatrica Scandinavica 120, 363–372. [2] Miyamoto, S., Miyake, N., Jarskog, L.F., Fleischhacker, W.W., Lieber- man, J.A., 2012. Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry 17, 1206–1227. [3] Le Pen, G., Gourevitch, R., Hazane, F., Hoareau, C., Jay, T.M., Krebs, M.O., 2006. Peri-pubertal maturation after developmental dis- turbance: a model for psychosis onset in the rat. Neuroscience 143, 395–405. P.2.e.010 Effects of maternal depression and venlafaxine treatment on the neurobehavioural development of the juvenile rat offspring E. Cs´ asz´ ar 1° , K. Beloviˇ cov´ a 1 , E. Ujhazy 1 , M. Mach 1 , M. Dubovick´ y 1 1 Institute of experimental pharmacology and toxicology, Department of developmental and behavioral toxicology, Bratislava, Slovak Republic Depression during pregnancy and in the post partum period is a growing health issue in modern society. An important question is whether to treat or not to treat depression during gestation and lactation. However previous preclinical and clinical studies have shown that the consequences of not treated depression can be so serious that the benefit from antidepressant therapy may overweight the possible risk for neonatal and/or postnatal development of the offspring. Venlafaxine, a representative of serotonine and noradrenaline reuptake inhibitors, is used to treat a wide spectrum of mood disorders. Thus, the limited number of prenatal and perinatal studies raises the question about the safety of venlafaxine therapy during gestation and lactation. Our previous experimental studies showed that pre- and early postnatal exposure to venlafaxine alone affected anxiety- and depression- like behavior in adult rat offspring of both sexes, though not necessarily in a negative way. However, we did not evaluated the action of venlafaxine in conditions of maternal depression. Unpredictable chronic mild stress before mating is commonly used in experimental animals to induce maternal adversity manifested by signs similar to depression. In the present study, we investigated the effect of venlafaxine treatment on selected reproductive and neurobehavioral variables of the juvenile offspring using a model of maternal adversity. Stressed and non-stressed Wistar rat dams were treated with either venlafaxine (10 mg/kg/day) or vehicle. Dams were divided into four groups: (1) Control + Vehicle, (2) Control + Venlafaxine, (3) Stress + Vehicle and (4) Stress + Venlafaxine. Venlafaxine was administered to the dams from day 15 of gestation to day 20 post partum via cookies. The results of the present study showed that mild maternal stress and/or administration of venlafaxine during gestation and lactation did not cause any major alterations in reproductive variables of the newborn offspring right after the birth. There were no differences in the duration of the pregnancy, litter weight of the offspring after the birth and also no alterations in the number of the living born pups. Nevertheless, dams previously exposed to stress had higher incidence of spontaneous abortions compare to non-stressed moth- ers. Moreover offspring of stressed mothers showed higher weight gain in the age of 35 days post partum. Maternal stress and venlafaxine do not affect play behavior of juvenile offspring in their familiar environment. However pups exposed to venlafaxine via their mother showed increased anxiety-like behavior in the new unfamiliar environment. In conclusion, we suggest that exposure to maternal stress and venlafaxine treatment during gestation and lactation may interfere with functional development of the brain and can cause neurobehavioral alterations. However these func- tional changes may not occur immediately after birth. They can manifest later during adolescence or even in adulthood and senes- cence as delayed and/or long-term neurobehavioral dysfunctions.