Supported by A Journal of Accepted Article Title: Approaching the Kinetic Inertness of Macrocyclic Gd3+-based MRI Contrast Agents with Highly Rigid Open-Chain Derivatives Authors: Gyula Tircs ´ o; Mart´ ın Regueiro-Figueroa; Vikt ´ oria Nagy; Zolt´ an Garda; Tam ´ as Garai; Ferenc Kriszti´ an K ´ alm ´ an; David Esteban-G ´ omez; ´ Eva T ´ oth; Car- los Platas-Iglesias This manuscript has been accepted after peer review and the authors have elected to post their Accepted Article online prior to editing, proofing, and formal publication of the final Version of Record (VoR). This work is currently citable by using the Digital Object Identifier (DOI) given below. The VoR will be published online in Early View as soon as possible and may be different to this Accepted Article as a result of editing. Readers should obtain the VoR from the journal website shown below when it is pu- blished to ensure accuracy of information. The authors are responsible for the content of this Accepted Article. To be cited as: Chem. Eur. J. 10.1002/chem.201503836 Link to VoR: http://dx.doi.org/10.1002/chem.201503836