Journal Pre-proofs Design, Synthesis, and Pharmacological Evaluation of Novel and Selective COX-2 Inhibitors Based on Bumetanide Scaffold Tarek S. Ibrahim, Ibrahim M. Salem, Samia M. Mostafa, Osama I. El- Sabbagh, Mohamed K.M. ElKhamisi, Lamees Hegazy, Bahaa Elgendy PII: S0045-2068(19)31765-1 DOI: https://doi.org/10.1016/j.bioorg.2020.103878 Reference: YBIOO 103878 To appear in: Bioorganic Chemistry Received Date: 18 October 2019 Revised Date: 11 April 2020 Accepted Date: 21 April 2020 Please cite this article as: T.S. Ibrahim, I.M. Salem, S.M. Mostafa, O.I. El-Sabbagh, M.K.M. ElKhamisi, L. Hegazy, B. Elgendy, Design, Synthesis, and Pharmacological Evaluation of Novel and Selective COX-2 Inhibitors Based on Bumetanide Scaffold, Bioorganic Chemistry (2020), doi: https://doi.org/10.1016/j.bioorg. 2020.103878 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Inc.