www.scholarsresearchlibrary.com t Available online a Scholars Research Library Der Pharmacia Lettre, 2015, 7 (10):185-187 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 185 Scholar Research Library Comparative anthelmintic activity of ethanolic extracts of Hibiscus rosa- sinensis linn. flower with Aegle marmelos leaves Krishn Kumar Agrawal*, Umesh Kumar Mishra, Kuldeep Singh and Preeti Mishra Raja Balwant Singh Engineering Technical Campus, Faculty of Pharmacy, Bichpuri, Agra, U.P., India _____________________________________________________________________________________________ ABSTRACT The objective of present study was to compare the anthelmintic activity of ethanolic extract of Aegle marmelos leaves and flowers of Hibiscus rosa-sinensis by using Indian earthworms (Pheretima posthuma). Various standards such as Piperazine citrate, Albendazole and Pyrantel pamoate at concentration of 20 mg/ml were used to compare anthelmintic activity with the extracts (Aegle marmelos and Hibiscus rosa-sinensis) at the same concentration in terms of paralysis time and death time of worms. The result revealed that ethanolic extract of Hibiscus rosa-sinensis flower have better paralyzing effect and less cidal effect as compared to ethanolic extract of Aegle marmelos leaves but both the extract did not have better activity than standards. Keywords: Piperazine citrate, Albendazole, Paralysis, Pyrantel pamoate _____________________________________________________________________________________________ INTRODUCTION Hibiscus is a large genus that contains herbs, shrubs and trees widely distributed in the tropical and sub-tropical region of world. Hibiscus rosa-sinensis Linn. (Malvaceae) is commonly known as jasut in Hindi and China rose in English. It is an evergreen woody, glabrous, showy shrub of 5-8 ft in height. Leaves are bright green, ovate, coarsely toothed above, flower are solitary, axillary, bell shaped, large 4-6 inch in diameter with pistil and stamens projecting from the centre [1] . Folklorically the flowers are used as demulcent, emollient, refrigerant, aphrodiasic emmenagogue and as anthelmintic [2] . A decoction of flower is used in bronchial catarrh. The dark red petals in the form of mucilaginous infusion are used in ardor-urinae, strangury, cystitis and other irritable conditions of the genito-urinary tract [3] . The flower of Hibiscus rosa-sinensis were reported to possess various activity such as analgesic [4] , anticonvulsant [5] , antidiabetic [6] , antipyretic [7] , wound healing [8] , antibacterial [9] , immunomodulatory [10] , antiestrous [11] , antioxidant [12] and hair growth [13] . Aegle marmelos is also known as bael, golden apple is a species of tree native to India. All parts of plants i.e. roots, fruit and leaves are used as medicinal purposes. The bael fruit has a smooth, woody shell with a green, gray or yellow peel. The essential oil of the bael tree to be effective aganst 21 types of bacteria. The juice of bael fruit is generally used for constipation and gastrointestinal problems [14] . MATERIALS AND METHODS Plant material: The flowers of Hibiscus rosa-sinensis Linn and leaves of Aegle marmelos were collected from the gardens of Mathura district, Uttar Pradesh and aunthentified by Birbal Sahni Institute of Palaeobotany, Lucknow, Uttar