_____________________________________________________________________________________________________ *Corresponding author: E-mail: g_ahtesham@yahoo.com; Journal of Pharmaceutical Research International 33(33B): 203-208, 2021; Article no.JPRI.62972 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Incidence and Management of Post Cholecystectomy Biliary Fistula at Tertiary Care Hospital Ahtesham-Ul-Haq 1* , Sohail Ahmed Memon 1 , Riaz Ahmad Memon 1 , Bilal Rasool 1 , Shahnawz Khatti 1 and Shahida Khatoon 1 1 General Surgery Department of LUMHS, Jamshoro, Sindh, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. Authors AUH and SAM designed the study, wrote the protocol and wrote the first draft of the manuscript. Author RAM, BR and SK managed the manuscript writing and analyses of the study. Author SHK literature search and guidelines. All authors read and approved the final manuscript. Article Information DOI:10.9734/JPRI/2021/v33i33B31812 Editor(s): (1) Dr. P. Veera Muthumari, V. V. Vanniaperumal College for Women, India. Reviewers: (1) Anonymous, USA. (2) Maglio Riccardo, Hospital Lecce, Italy. Complete Peer review History: http://www.sdiarticle4.com/review-history/62972 Received 01 September 2020 Accepted 04 December 2020 Published 30 June 2021 ABSTRACT Objective: To determine the incidence and management of post cholecystectomy biliary fistula at tertiary care Hospital. Methodology: This was a prospective study which was conducted at general surgery department of Liaquat University of Medical and health Sciences, during one year from March 2017 to February 2018. All the patients those underwent laparoscopic cholecystectomy or open cholecystectomy, age more than15 years and either of gender were included. All the patients were evaluated for developed biliary fistula after cholecystectomies. All the patients of biliary fistula were managed conservatively and surgically and their management outcome was recorded. After operation most of patients were followed up to 6 months. The data was collected via study designed proforma. Data was analyzed by using SPSS version 20. Results: Out of 318 patients, 280 patients underwent laparoscopic cholecystectomies, 38 patients underwent open cholecystectomies. Mean age of the patients was 41.34+ 8.23 years. Females were in majority 233(73.3%) and males were 95(29.7%). Out of all post-cholecystectomy biliary fistula was seen in 10(3.14%) patients. Incidence of post-cholecystectomy biliary fistula was insignificantly associated with types of cholecystectomies (p=0.425), while it was highly prevalent in Original Research Article