1 Supporting Information Transformable nanotherapeutics enabled by ICG: Towards enhanced tumor penetration under NIR light irradiation Yuxiang Tang a,b,# , Yihui Li a,b,# , Si Li a,b,# , Hang Hu a,b , Yuxin Wu a,b , Chen Xiao a,b , Zhiqin Chu c , Zifu Li a,b,d,e,* , and Xiangliang Yang a,b,d a Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China b National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China c Department of Electrical and Electronic Engineering, Joint appointment with School of Biomedical Sciences, The University of Hong Kong, Hong Kong d Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, 430074, China e Wuhan Institute of Biotechnology, High Tech Road 666, East Lake high tech Zone, Wuhan, 430040, China Author Contributions: # These three authors contributed equally to this work. * Corresponding author: Professor Zifu Li Tel.: 86 27 87792234, Fax: 86 27 87792234, E-mail: zifuli@hust.edu.cn Electronic Supplementary Material (ESI) for Nanoscale. This journal is © The Royal Society of Chemistry 2019