This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/bab.1694. This article is protected by copyright. All rights reserved. Novel bioactive porous starch-siloxane matrix for bone regeneration: physicochemical, mechanical, and in-vitro properties Amir Aidun 1, 2 , Ali Zamanian 3,4* , Farnaz Ghorbani 3,4,5 1 National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran 2 Tissues and Biomaterials Research Group (TBRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran 3 Biomaterials Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Tehran, Iran. 4 Skin & Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. 5 Department of Biomedical Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran. * Corresponding author: A. Zamanian Mobile: + 98 (912) 3211180; Tel: + 98 (263) 6280033x332. Email: a-zamanian@merc.ac.ir Short running title: Bioactive starch-GPTMS scaffolds Abstract So far, many studies have focused on biodegradable scaffolds for tissue engineering purposes. Herein, a starch-based biodegradable scaffold was fabricated by the freeze-drying method and cross-linked using a different concentration of 3-glycidoxypropyl- trimethoxysilane (GPTMS). Field emission scanning electron microscopy (FE-SEM) micrographs indicated an interconnected porous microstructure in which the porosity