TJ ISSN 0300-8916 Tumori 2016; 102(Suppl 2): S61-S64 © 2015 Wichtg Publishing Case report was no history of cough, chest pain, vomitng, icterus, or bowel or bladder dysfuncton. There was no history of any co- morbid conditon or signifcant disease in the family. General physical examinaton was normal except for mild pallor. Ab- domen examinaton revealed massive splenomegaly and mild hepatomegaly. Laboratory results showed anemia (10 g/dL), thrombocytopenia (40,000/µL), and leukocytosis (15,300/µL). Peripheral smear revealed normocytc, normochromic red blood cells with mild anisocytosis, few target cells, and How- ell Jolly bodies. Retculocyte count was 3.98%, suggestve of a hemolytc picture. Malaria and kala-azar infectons were ex- cluded. Liver functon tests were abnormal, with bilirubin of 3 mg/dL (normal range 0.3-1.9 mg/dL), alanine aminotrans- ferase 80 IU/L, and aspartate aminotransferase 120 IU/L (nor- mal range 0-40 IU/L). HBeAg was positve with high hepatts B virus DNA load of 2.4 × 108 copies/mL. Viral serology for hepatts C, hepatts D, and human immunodefciency virus 1 and 2 was negatve. Abdominal ultrasonography confrmed marked splenomegaly and mild hepatomegaly. No enlarged lymph nodes were identfed. The patent underwent sple- nectomy and liver wedge biopsy. Subsequently bone marrow aspiraton and biopsy was done. Gross examinaton revealed an enlarged spleen measur- ing 33 × 21 × 10 cm and weighing 2900 g. Cut surface was reddish brown, homogenous, and feshy, with an area of in- farcton. No nodularity or follicular prominence was noted. Wedge biopsy of liver measured 1 × 0.8 × 0.5 cm. Cut surface was unremarkable. Microscopic examinaton of the spleen showed difuse in- volvement of the red pulp by small to medium-sized lymphoid cells with a thin rim of pale cytoplasm and irregular nuclei. DOI: 10.5301/tj.5000445 Hepatosplenic t-cell lymphoma with coexistent hepatts B infecton: a rare clinicopathologic entty Fouzia Siraj 1 , Varsha Dalal 1 , Afaq A. Khan 2 , Deepali Jain 3 1 Natonal Insttute of Pathology (ICMR), New Delhi - India 2 JLNM Hospital, Srinagar, Kashmir - India 3 Department of Pathology, AIIMS, New Delhi - India Introducton Hepatosplenic T-cell lymphoma (HSTL) is a rare peripheral T-cell lymphoma derived from cytotoxic T-cells, and manifests as an extranodal systemic lymphoma (1). It is characterized by primary extranodal disease with typical sinusoidal infltra- ton of the liver and the spleen. The neoplasm is seen mostly in adolescents and young adults with a strong predilecton for males (2, 3). Hepatosplenic T-cell lymphoma has been re- ported in the context of immunosuppressive states and cer- tain infectons (1, 4). There is a possibility that proliferaton of neoplastc T cells in response to infectve agents like hepatts B, as seen in the present case, plays a role in the pathogenesis of hepatosplenic T-cell lymphoma. Case report A 29-year-old man presented with fever, abdominal pain, and signifcant weight loss for a period of 5 months. There ABStrACt Background: Hepatosplenic T-cell lymphoma (HSTL) is a rare extranodal and systemic lymphoma derived from cytotoxic T cells usually of γδ T cell receptor type. It is characterized by primary extranodal disease with typical sinusoidal infltraton of liver, spleen, and bone marrow by medium-sized lymphoid cells. Case report: A 29-year-old man, with no signifcant prior medical history, presented with fever and massive sple- nomegaly. A diagnosis of HSTL was established by histologic examinaton and immunohistochemistry. Staging workup demonstrated bone marrow involvement by lymphoma. In additon, the patent was found to have hepa- tts B infecton. The associaton of these 2 enttes has been described rarely. Conclusions: Hepatosplenic T-cell lymphoma is a distnct T cell lymphoma associated with an aggressive clinical course, a poor response to conventonal treatment, and an exceedingly high mortality rate. An associaton of HSTL with hepatts B as seen in the present case is exceedingly rare, with few cases reported in the literature. Keywords: γδ T cell receptor, Hepatts B, Hepatosplenic T-cell lymphoma Accepted: September 17, 2015 Published online: October 13, 2015 Corresponding author: Varsha Dalal Senior Resident Natonal Insttute of Pathology (Indian Council of Medical Research) Sriramachari Bhawan Safdarjung Hospital Campus New Delhi 110029, India vndreamon12@gmail.com