1 A Case Report of Canine Oral Papilloma Treated Successfully with Homeopathic Medicine 1 S. Jibachha, 2 S.P. Kumar, 2 S. J. Kumari 1 Jibachha Veterinary Hospital Research & Training Center (p) Ltd.Bharatpur-4, Chitwan, Nepal 2 Jibachha Veterinary Hospital (p) Ltd. Jhamshikhel, Lalitpur, Nepal Corresponding author: Dr. Jibachha Sah, 1 Jibachha Veterinary Hospital Research & Training Center (p) Ltd.Bharatpur-4, Chitwan, Nepal jibachhashah@gmail.com ABSTRACT In Nepal, homeopathic medicine is rarely used in veterinary practice. Therefore, this article aimed to report the successful treatment of oral papillomatosis in two young dogs of German shepherd breeds using homeopathic therapy. A total of two dogs aged between 7 and 8 months, brought from Dhading district to the Jibachha Veterinary Hospital, Bharatpur, Chitwan, they were employed in this research. Clinical examination was used to make the canine oral papillomatosis diagnosis. A combination of Thuja- 30C, Calcaria carb-30C, Antimony crudum-30C, Causticum-30, Dulcmara-30C, and Acid nitricum-30 were given 5 drops each twice a day orally, and the oral papillomas completely disappeared within two weeks with no relapse. The combination of homeopathic medicine continued for more than two weeks after complete regression. Key words: Oral papillomatosis, homeopathic medicine, canine 1. Introduction The papillomavirus is the root cause of dog warts, sometimes referred to as papillomas, which are prevalent skin disorders in canines. These benign, painless growths on dogs' skin have a cauliflower-like look. Anywhere on the body of the dog may develop warts as a result of this highly contagious virus. But they mostly occur around the mouth and head. Oral papillomas are warts that appear on the lips or inside the mouths of dogs. The first occurrence of papillomatosis in dogs was recorded in 1898 (Nicholls and Stanley, 1999). The etiology of papillomatosis was identified in 1959 (Nicholls and Stanley, 1999) and is linked to the infection caused by the papillomavirus, a DNA virus with double strands but no envelope is related to a great number of cutaneous and mucosal manifestations (Hnilicia and Patterson, 2017). Papillomatosis has a high rate of morbidity and a low rate of mortality with a favorable prognosis and no disease recurrence since the patient acquires immunity to the virus (Favrot, 2012). The elderly and/or immunocompromised animals become more susceptible to papillomavirus infection. Treatment is controversial and can be performed in different ways. Surgery is the most commonly used therapy among conventional veterinarians. However, some professionals choose not to treat when the diagnosis is made at the onset of the disease, as spontaneous regression may occur within four weeks. Other treatment options for persistent cases include cryotherapy, chemotherapy with vincristine or cyclophosphamide, and autogenous vaccines (Sherding, 2008), auto-hemotherapy, laser therapy, antibiotic therapy, topical applications with fluorouracil or T. occidentalis (Agnihotri et al., 2015), and