Pharmacology & Pharmacy, 2021, 12, 127-140 https://www.scirp.org/journal/pp ISSN Online: 2157-9431 ISSN Print: 2157-9423 DOI: 10.4236/pp.2021.127012 Jul. 20, 2021 127 Pharmacology & Pharmacy Evaluation of the Preventive and Therapeutic Activities of Tridax procumbens against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats Jean-Baptiste Amagbegnon 1 , Omédine Koukoui 1 , Pascal C. Agbangnan 2 , Santorin Seton 1 , Mansouratou Betira 1 , Sedami Medegan 3 , Laura Loko 4 , Victorin Dougnon 5 , Luc Djogbenou 6 , Alphonse Sezan 7 1 Laboratory of Animal Physiology, Cellular Signalisation and Pharmacology, University of Sciences Technologies, Engineering and Mathematics, Dassa Zoume, Benin 2 Laboratory of Study and Research in Applied Chemistry, Unity of Research and Molecular Interactions (URIM/LERCA/UAC), Cotonou, Benin 3 Medicinal and Organic Chemistry Laboratory, Faculty of Health Sciences, Cotonou, Benin 4 Laboratory of Applied Entomology, University of Sciences Technologies, Engineering and Mathematics, Dassa Zoume, Benin 5 Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory for Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin 6 Laboratory of Infectious Vector Borne Diseases, Regional Institute of Public Health, University of Abomey-Calavi, Abomey-Calavi, Benin 7 Laboratory of Biomembranes and Cellular Signalisation, University of Abomey-Calavi, Cotonou, Benin Abstract From the Asteraceaes family, Tridax procumbens is a wild species frequently found in fields, meadows and roadsides. It is traditionally used to treat yellow fever, typhoid fever, high blood pressure and diabetes. In this work we used the hydro-ethanolic extract of the leaves and stems of the plant and also the fractions of this extract to determine the preventive and therapeutic activities of the plant against obesity, hyperglycemia and hyperlipidemia. The yields of the fractions obtained by decantation of the hydro-ethanolic extract are re- spectively 0.160% with hexane, 0.073% with dichloromethane, 0.09% with di- ethyl ether and 0.150% with ethyl acetate. Hyperglycemia and hyperlipidemia were induced in the rats submitted to a fatty and sweet diet for 28 days. Our results showed a significant increase in glycemia, weight and triglyceride level in rats that were subjected to the diet. On the other hand, the rats treated with the dose of 500 mg/kg of body weight of Tridax procumbens extract during the induction showed a reduction in weight gain and an absence of increase How to cite this paper: Amagbegnon, J.-B., Koukoui, O., Agbangnan, P.C., Seton, S., Betira, M., Medegan, S., Loko, L., Dougnon, V., Djogbenou, L. and Sezan, A. (2021) Evalu- ation of the Preventive and Therapeutic Ac- tivities of Tridax procumbens against Hy- perglycemia and Hyperlipidemia Induced in Wistar Rats. Pharmacology & Pharmacy, 12, 127-140. https://doi.org/10.4236/pp.2021.127012 Received: May 26, 2021 Accepted: July 17, 2021 Published: July 20, 2021