hematol transfus cell ther. 2 0 2 0; 4 2(2) :176–179 www.htct.com.br Hematology, Transfusion and Cell Therapy Case Report Organizing pneumonia in a patient with hodgkin’s lymphoma and large B cell lymphoma: a rare association Jaume Bordas-Martinez * , Mercè Gasa, Eva Domingo-Domènech, Vanesa Vicens-Zygmunt Bellvitge Universitary Hospital, L’Hospitalet, Barcelona, Spain a r t i c l e i n f o Article history: Received 1 May 2019 Accepted 7 June 2019 Available online 7 September 2019 Organizing Pneumonia (OP) is classified as an Idiopathic Interstitial Pneumonia (IIP). 1 Clinically, the patients present dyspnea, cough, and low fever, and usually respond well to corticosteroids, reaching clinical and radiologic resolution in a short timeframe. However, sometimes infiltrates do recur and may not resolve. Radiologically, migratory consolida- tions are identified in high-resolution computed tomography (HRCT), sometimes associated with progressive fibrosis with reticulation and areas of persistent consolidation. 1 The his- tology reveals “proliferation of fibroblastic tissue within small airways, alveolar ducts, and alveolar spaces”. 2 OP can be secondary to other pathologies such as common variable immunodeficiency 3 and malignant disease among others. 4 At times no etiology is identified and the term Cryptogenic Organizing Pneumonia (COP) is used. 1 Furthermore, OP could coexist or mimic a malignant disease. 4,5 We present a case of a 56-year-old (y/o) man, ex-smoker of 19 pack-years, an engineer without any contact with chemical products. He lived in a flat without detectable expo- sures, and indicated no alcohol or drug abuse. In 2002 (41 * Corresponding author at: Department of Pulmonology, Bellvitge University Hospital, c/FeixaLlarga S/N, L’Hospitalet, 08907, Barcelona, Spain. E-mail address: jbordas@bellvitgehospital.cat (J. Bordas-Martinez). y/o), he was monitored by other center due to dispnea, non-productive cough and low-grade fever. There were no remarkable indicators during physical examination (no patho- logical breathing sounds, 98% oxygen saturation at room air). Laboratory studies highlighted neutrophil-predominant leukocytosis and elevated level of C-reactive protein. X-ray findings and High-Resolution Computed Tomography (HRCT) showed lung infiltrates that migrated from one relapse to the other. We do not dispose from other data (bronchoalveolar lavage. . .). Initially, the clinical situation and infiltrates had complete remission with 15 mg per day of corticosteroids (CS). He remained asymptomatic for a long period of time (several months to a year). However, the time he remained free of infil- trates shortened and required increasing doses of cortisone up to 30 mg per day. Subsequently the patient could not dis- continue corticosteroid use because his respiratory condition worsened during the periods free of infiltrates. He became CS- resistant in 2011 requiring 15 mg per day minimum. During this time, he required hospitalization for some of the recur- rences (2002, 2004(x2), 2008, 2011). For every hospitalization, https://doi.org/10.1016/j.htct.2019.06.003 2531-1379/© 2019 Associac ¸˜ ao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).