1235 National Journal of Physiology, Pharmacy and Pharmacology 2018 | Vol 8 | Issue 8 RESEARCH ARTICLE Effect of age on cardiac output after coronary angioplasty in patients of acute myocardial infarction Samir Kumar Singh 1 , Manish Bajpai 2 , Sunita Tiwari 2 , Rishi Sethi 3 , Dileep Kumar Verma 2 , Gaurav Chaudhary 3 1 Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India, 2 Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India, 3 Department of Cardiology, King George’s Medical University, Lucknow, Uttar Pradesh, India Correspondence to: Samir Kumar Singh, E-mail: drskss01@gmail.com Received: May 25, 2018; Accepted: June 12, 2018 ABSTRACT Background: Although most of the acute coronary syndrome (ACS) patients are elderly, less data available on the effect of age on outcome after percutaneous coronary interventions (PCI) and major adverse cardiovascular events. In this study, we evaluated the effect of age on clinical outcomes in patients with ACS undergoing PCI because it is a well-known fact that the ages of patients influence clinical outcomes in ACS. Aims and Objectives: The aim of the study was to find out the effect of age on outcome of angioplasty in acute myocardial infarction (AMI) patients. Materials and Methods: It is a cross-sectional, self- control, interventional study. In this study, cardiac output (CO) of 52 patients of AMI was measured by echocardiography before and after angioplasty. CO is calculated with the help of end diastolic volume, end systolic volume, and left ventricular outflow tract diameter. Statistical software IBM SPSS version 16 was used for analysis of data. Results: A negative and statistically significant coefficient of correlation (r = −0.384 and P = 0.005) was found between age of patients and the value of CO after coronary angioplasty. Linear regression analysis was also done taking CO after coronary angioplasty as dependent variable and age of the patient as the independent variable. It can be hypothesized that as the age advances, CO after angioplasty deteriorates. Conclusion: Advancing age is associated with deterioration in outcome after coronary angioplasty in AMI patients. KEY WORDS: Acute Myocardial Infarction; Age; Cardiac Output INTRODUCTION In present days, the elderly population is having a longer lifespan; however, Saunderson et al. noticed that the prevalence of cardiovascular diseases is increasing as the age advances. [1] Some authors found that the cardiac output decreases with age. However, some authors noticed that the Access this article online Website: www.njppp.com Quick Response code DOI: 10.5455/njppp.2018.8.0620312062018 National Journal of Physiology, Pharmacy and Pharmacology Online 2018. © 2018 Samir Kumar Singh, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. cardiac output does not always change with ages. Cardiac function can be assessed with the help of resting cardiac output. Critically ill patients with cardiac pathology cannot be easily assessed for hemodynamic parameters so different methods are used for the assessment of various hemodynamic parameters. However, these invasive and non-invasive methods have their advantages and disadvantages. Starr et al. investigate cardiac output in older “normal” adults using the indirect gas methods. They found that the average cardiac index start declining after 20 years of age and there was a significant decrease in cardiac index after 50 years of age. [2] National Journal of Physiology, Pharmacy and Pharmacology