SCREENING OF NOVEL ANTIASTHMATIC CONSTITUENT OF LOBELIA NICOTINAFOLIA BY DOCKING Suraj Patil 1 , Abhinandan Patil 1 *, Aarti Chavan 1 , Nita Pawar 2 1. School of Pharmaceutical Sciences, Sanjay Ghodawat University, Kolhapur, India 2. Bharati Vidyapeeth Institute of Pharmacy CBD Belapur, Navi Mumbai, India. ABSTRACT The docking of selected protein with ligand was performed by using Hex 8.0.0. Cuda1. Hex is an interactive molecular graphics program for calculating and displaying feasible docking mode pair of protein and of DNA molecule. The three-dimensional structure, of histamine receptor, INOS was obtained from protein data bank (PDB). This structure was determined using X ray diffraction missing atom and loop were corrected by Prepare protein module under Accelrys. Discovery Studio 4(DS4); residue of were protonated of histamine receptor in pH 7.4 condition. The phytoconstituents which was selected for study shown better results in terms of ADME properties as well as drug likeness model score of vasicoline. The docking energy of vasicolinon receptor occupancy was satisfied as compare to standard used lobelanine Keywords: - Proteins, DNA, Antihistamine, Lobelia nicotinafolia