International Surgery Journal | May 2022 | Vol 9 | Issue 5 Page 991 International Surgery Journal Gawali A et al. Int Surg J. 2022 May;9(5):991-996 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 Original Research Article Clinical profile and management of chronic pancreatitis in tertiary care centre Amey Gawali*, Nitin Wasnik, Rajiv Sonarkar, Satish Deshmukh INTRODUCTION Constant inflammation and irreversible pancreatic tissue destruction are hallmarks of the disease of chronic pancreatitis, which results in the gradual loss of both exocrine and endocrine function. 1 It is a multifactorial disease, with a wide range of symptoms and geographic variation. The incidence of chronic pancreatitis in the western population ranges from 8 to 10 cases yearly per 100,000 population, and the overall prevalence is 27.4 per 100,000 per year. 2 According to a recent survey conducted in various countries in the Asia-Pacific region, chronic pancreatitis is prevalent in Southern India, with 114-200 cases per 100,000 people. 3 In the Indian subcontinent, there has been no systematic nationwide study on the management of clinical profiles. 3 Some of the possible causes of chronic pancreatitis include alcohol abuse (malignancy or stones), ductal obstruction (cystic fibrosis or hereditary pancreatitis), chemotherapy and autoimmune diseases such as SLE or pancreatitis. According to recent research, the disease may be caused by a lack of certain vitamins and antioxidants. 4,5 Drinking alcohol is the most common cause. Protein secretion from acinar cells increases, resulting in ductal obstruction, acinar fibrosis, and atrophy as a result of the alcohol. 4,5 Chronic pancreatitis appears to be caused by a combination of genetic and environmental factors. Several genes have been linked to ABSTRACT Background: Chronic pancreatitis is a multifactorial disease, with a wide range of symptoms and geographic variation. Aim of this study is to study clinical profile and management of chronic pancreatitis with respect to demography, clinical findings, lab parameters, imaging investigations and management modalities. Methods: A cross sectional observational study was conducted which included the patients admitted in tertiary care centre presenting with clinical diagnosis of chronic pancreatitis. The study was conducted over period of 2 years from November 2019 to October 2021. A total sample size of 71 patients were included. Results: In the study, it was observed that majority of patients in age group of 51-60 years which were male (76.06%). Alcoholism (43.66%) was most common etiology and presented with pain in abdomen (85.92%). In the present study, majority of patients were managed conservatively (43.66%).The distribution of patients according to pain relief by various management showed that majority of get relief of pain by surgery (69.23%). Conclusions: Chronic pancreatitis is progressive inflammatory disease. Alcoholic pancreatitis being most common etiology. Pain is most common presenting symptom. CT-SCAN abdomen most useful in confirming diagnosis in our set up. Pseudocyst being common complication seen. Surgery gives relief of pain in most of the cases. Keywords: Chronic pancreatitis, Alcohol, Pseudocyst Department of Surgery, NKP Salve Medical College, Nagpur, Maharashtra, India Received: 20 January 2022 Revised: 30 March 2022 Accepted: 01 April 2022 *Correspondence: Dr. Amey Gawali, E-mail: ameygawali007@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.18203/2349-2902.isj20221144