Journal Pre-proof Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies Qian Xu, Zheng Zhang, Lei Zhao, Yun Qin, Haodong Cai, Zhe Geng, Xiaojian Zhu, Wei Zhang, Yuanyuan Zhang, Jiaqi Tan, Jue Wang, Jianfeng Zhou PII: S0168-3659(20)30417-X DOI: https://doi.org/10.1016/j.jconrel.2020.07.033 Reference: COREL 10429 To appear in: Journal of Controlled Release Received date: 8 May 2020 Revised date: 15 July 2020 Accepted date: 18 July 2020 Please cite this article as: Q. Xu, Z. Zhang, L. Zhao, et al., Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies, Journal of Controlled Release (2020), https://doi.org/10.1016/ j.jconrel.2020.07.033 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier.