Ankit Kumar Tiwari et al JMSCR Volume 09 Issue 06 June 2021 Page 88 JMSCR Vol||09||Issue||06||Page 88-92||June 2021 Original Research Article Status of Oxidative stress in the Patient of primary open angle glaucoma with type-2 Diabetes mellitus Authors Ankit Kumar Tiwari 1 , K Suresh Babu 2 , Shreya Nigoskar 3* , Sonalee Mittal 4 1 Research Scholar, Department of Biochemistry,Index Medical College Hospital & Research Centre, Malwanchal University, Indore, Madhya Pradesh 2 Professor, Department of Biochemistry, Symbiosis Medical College for Women, Pune, Maharashtra, India 3 Professor & HOD Department of Biochemistry, Malwanchal University, Indore, Madhya Pradesh, India 4 Professor, Department of Ophthalmology, Index Medical college hospital and research Centre, Malwanchal University, Indore, Madhya Pradesh, India *Corresponding Author Dr Shreya Nigoskar Professor & HOD, Department of Biochemistry, Index Medical College Hospital and Research Centre, Malwanchal University, Indore, Madhya Pradesh, India Abstract Introduction: Primary open-angle glaucoma (POAG) is a chronic and age-related disease that is the leading cause of irreversible visual disability. Primary open-angle glaucoma is known to be associated with diabetes mellitus (DM) type 2 and hypertension. Glaucoma is a progressive optic neuropathy and is the leading cause of blindness in the developing and industrialized countries. Aim and Objective: Assessment of antioxidant enzyme in Type-2 Diabetes mellitus primary open angle glaucoma patients, diabetes without Primary open-angle glaucoma as compared to normal controls. Material and Methods: A total of 100 patients, 100 - Type-2 Diabetes mellitus Primary open-angle glaucoma patients from the last one year and 100 normal healthy individuals were chosen as a control group. Results: The mean values of FBS, were significantly increased (P<0.001) in type -2 Diabetes mellitus Primary open-angle glaucoma, diabetes without Primary open-angle glaucoma cases as compared to normal healthy individuals. significantly decreased levels of antioxidant enzyme activity (SOD, CAT, GPx) levels in Type-2 DM with Primary open angle glaucoma, Diabetes without (POAG) as compared to the controls groups (p<0.001). Keywords: Primary open-angle glaucoma, FBS and antioxidant enzymes (SOD, CAT, GPx) Type – 2 diabetes mellitus. Introduction Glaucoma, characterized by progressive “glaucomatous” optic neuropathy and corresponding visual field loss, is a leading cause of irreversible blindness worldwide [1] . Primary open-angle glaucoma (POAG) is a chronic and age-related disease that is the leading cause of irreversible visual disability. 2 http://jmscr.igmpublication.org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v9i6.18