This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/JCPE.13361 This article is protected by copyright. All rights reserved Dysregulation of genes and microRNAs in Localized Aggressive Periodontitis Running title: Periodontitis miRNAs and gene expression Jussara Gonçalves Fernandes 1 , Lorri Ann Morford 2 , Peter Lloyd Harrison 3,4 , Theodora Kompotiati 3 , Hong Huang 3 , Ikramuddin Aukhil 3 , Shannon Margaret Wallet 3,5 , Luciana Macchion Shaddox 1,3 . 1. Department of Oral Health Science, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA 2. Department of Oral Health Science, Division of Orthodontics, College of Dentistry, University of Kentucky, Lexington, KY, USA 3. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. * Corresponding Author: Luciana Macchion Shaddox 1095 VA Dr. Lexington KY, 40536 Phone 859-323-8269/ Fax. F: 859-257-6566 lshaddox@uky.edu 4 Division of Periodontology, School of Dental Science, Trinity College Dublin, Ireland 5 Department of Oral and Craniofacial Health Sciences, School of Dentistry, The University of North Caroline, Chapel Hill, NC, USA Accepted Article