Corresponding Author E-mail: ahmadi.iauk@gmail.com 1364 | Page http://www.ijabbr.com Available online at International journal of Advanced Biological and Biomedical Research Volume 1, Issue 11, 2013: 1364-1367 Synthesis of 2-Amino-4hydroxy-1H-pyrrole-3-carbonitrile from Glycine under Microwave Irradiation Sayed Ali Ahmadi *1 , Meysam Maddahi 2 1, 2 Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran ABSTRACT Reaction of Glycin with Malononitrile afforded respective Pyrrole. Pyrrole is one of the heterocyclic compounds with very important biological activities. Heterocycles are extremely important because of their wide range of applications that goes from their use as pharmaceuticals and agrochemicals to dyestuffs and additives. In this view, it was proposed to synthesize pyrrole-3-carbonitrile derivative. An efficient one-step protocol has been developed to make new molecules of this family. An expeditious synthesis of derivatives pyrrole has been developed by reacting Malononitrile and Glycine derivatives using a microwave. The structures of synthesized were assigned on the basis of IR and 1H NMR spectroscopy data. Keywords: Glycine, Malononitrile, Pyrrole. 1. INTRODUCTION N-Heterocycles receive considerable attention in the literature as a consequence of their exciting biological properties and their role as pharmacophores (Gribble et al., 1996). In these heterocycles, the pyrrole ring is one of the most fundamental. Pyrrole derivatives are considerable attention of synthetic importance and extensively used in drug discovery (Toja et al., 1987) and pharmacological activity such as anti-inflammatory (Joseph et al., 1985), cytotoxicity (Dannhardt et al., 2000; Khanna et al., 1997), in vitro cytotoxic activity against solid tumour models (Burnham et al., 1998; Gupton et al., 1999), treatment of hyperlipidemias (Justin et al., 2004), antitumour agents (Krowicki et al., 1998). The pyrrole containing heterocyclic derivatives have been reported in synthetic and effective biological importance (Almerico et al., 1998; Carpio et al., 1982). Pyrrole derivatives have biological activity such as COX- 1/COX-2 inhibitors (Dannhar et al., 2000) and cytotoxic activity against a variety of marine and human tumor models (Evans et al., 2003). The reaction of Malenonitrile with Glycine in the presence of piperidine was carried out, and the results were reported (Scheme 1).