Open Peer Review Any reports and responses or comments on the article can be found at the end of the article. CLINICAL PRACTICE ARTICLE Management of acute and post-operative pain in chronic kidney disease [version 2; peer review: 1 approved, 1 approved with reservations] Malvinder S Parmar , Kamalpreet S Parmar 2 Northern Ontario School of Medicine, Laurentian & Lakeland Universities, Ontario, P3E 2C6, Canada University of Queensland, Brisbane, Queensland, QLD 4072, Australia Abstract Chronic kidney disease is common and patients with many co-morbid conditions frequently have to undergo surgical procedures and, therefore, require effective pain management. The pharmacokinetics of various analgesic agents are not well studied in patients with chronic kidney disease and the risk of accumulation of the main drug or their metabolites, resulting in serious adverse events, is a common scenario on medical and surgical wards. It is common for these patients to be cared for by 'non-nephrologists' who often prescribe the standard dose of the commonly used analgesics, without taking into consideration the patient's kidney function. It is important to recognize the problems and complications associated with the use of standard doses of analgesics, and highlight the importance of adjusting analgesic dosage based on kidney function to avoid complications while still providing adequate pain relief. 1 2 1 2 Reviewer Status Invited Reviewers version 3 published 05 Apr 2013 version 2 published 08 Mar 2013 version 1 published 30 Jan 2013 1 2 report report report , Albany Medical College, New Howard S Smith York, NY, USA 1 , Mayo Clinic in Rochester, Paul E Carns Rochester, MN, USA 2 30 Jan 2013, :28 ( First published: 2 ) https://doi.org/10.12688/f1000research.2-28.v1 08 Mar 2013, :28 ( Second version: 2 ) https://doi.org/10.12688/f1000research.2-28.v2 05 Apr 2013, :28 ( Latest published: 2 ) https://doi.org/10.12688/f1000research.2-28.v3 v2 Page 1 of 14 F1000Research 2013, 2:28 Last updated: 16 MAY 2019