247 Copyright © All rights are reserved by Ahed J Alkhatib. Archives of Diabetes & Obesity Case Report ISSN: 2638-5910 Prediabetes can be Reversed Using Low Dose Tadalafil: Non- Classical Treatment of Diabetes as A New Medical Hypothesis Ahed J Alkhatib* 1, 2 1 Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan 2 International Mariinskaya Academy, Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology *Corresponding author: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan Received: August 24, 2020 Published: September 02, 2020 DOI: 10.32474/ADO.2020.02.000150 Introduction Type2 diabetes (T2D) can result from various reasons, it develops with time [1]. Lifestyle behaviors and environmental factors play significant roles in developing T2D [2]. Risk factors attributing to T2D include age, obesity, race, family history of T2D, abdominal adiposity and physical inactivity, and depression [1,3]. The prevalence of type 2 diabetes is dramatically increasing at international level [4]. The American Diabetes Association (ADA) defined pre-diabetes in terms of impairment in fasting glucose (5.6–6.9 mmol/L), or impairment in oral glucose tolerance test (2-h OGTT glucose 7.8– 11.0 mmol/L) [5]. Pre-diabetic can be determined by a low glucose tolerance and delayed insulin secretion [6]. Pre-diabetes may pass unnoticed because patients do not clinically exhibit specific symptoms that require medical interactions, and it needs to be investigated thoroughly because people may have various hypoglycemic states. Pre-diabetes can be fully developed into diabetes [7,8]. We have recently reported a paper about induction of pre- diabetic model in rats. We demonstrated in this study that the use of Urtica pilluliferain restoring pre-diabetic status into normal status in terms of glucose level, lipid profile, and oxidation stress [4]. However, our accumulated experience in diabetic studies showed that development of diabetes is associated with molecular changes in different tissues such as brain [9], and liver [10]. The most common feature in our studies is the upregulation of HSP70 as a factor showing improvement in diabetic status. Tadalafil is a member of phosphodiesterase-5 inhibitors, and it is widely used for the treatment of erectile dysfunction due to its long acting properties [11]. The use of tadalafil has been associated with antioxidant activities in blood and tissues [12-15].[16] reported the existence of certain benefits of using daily tadalafil Abstract Diabetes type 2 represents a global health problem, and it is expected to influence approximately 530 million people by 2030. Usually, diabetes type 2 is developed through more than one stage. Prediabetes is a preliminary stage of diabetes before developing full episodes of diabetes.Diabetes type 2 can be preventable following appropriate lifestyles. The main objective of this study is to describe a case with liver cirrhosis and the patient was recommended for liver transplantation. Following reviewing of his profile, it was apparent that the patient had prediabetes (glucose level was 126mg/dl). The patient was recommended to use tadalafil 5 mg daily to offer improvement of liver function based on previous experience. Glucose level was daily measured. It was interestingly found that glucose levels were restored to normal levels between 85-100 mg/dl. Taken together, prediabetes can be treated using non-classical therapeutic approaches and full events can be prevented accordingly. Keywords: Diabetes Type 2; Pre-Diabetes; Tadalafil; Glucose; Liver