214 ANNALS VOL 23, ISSUE 2, APR. – JUN. 2017 Frequency of Hypercholesterolemia in Recent Onset Type – 2 Diabetics with Microalbuminuria Muhammad Adnan Hasham, 1 Sakhawat Abbas, 2 Mirza Ilyas Baig, 3 Fawad Ahmad Randhawa 4 Abstract Amongst diabetes, type 2 diabetes encompasses more than 80% and even higher percentage is present in un- industrialized countries. Kidney disease in diabetic patients is clinically characterized by increasing rates of urinary albumin excretion, starting from no albumi- nuria, which progresses to microalbuminuria, macro- albuminuria and eventually to End Stage Renal Dise- ase. Dyslipidemia is observed in patients with DM and microalbuminuria. Total cholesterol increases signifi- cantly with albuminuria. Objectives: Frequency of hypercholesterolemia in recent onset type-2 diabetics with microalbuminuria. Methodology: The study was conducted in Depart- ment of Endocrinology & Metabolism, Services Hos- pital Lahore. Study was conducted and completed over a period of six months from 15 th September 2014 to 15 th March 2015. It was a cross-sectional survey with non-probability, purposive sampling technique. 200 patients fulfilling the criteria were enrolled. Informed 1 Senior Registrar, Endocrinology Unit & Diabetes Management Center, Services Hospital, Lahore 2 Consultant Physician, Kot Khawaja Saeed Hospital Lahore 3 Associate Professor, Fatima Memorial Hospital, Lahore 4 Assistant Professor of Endocrinology King Edward Medical University Date of Submission: 14-12-2016 Date of Acceptance for Publication: 10-05-2017 Conflict of Interest: None Funding Source: None Contribution All Authors have contributed in Study Design, Data Collection, Data Analysis, Data Interpretation, Manuscript Writing and Appr- oval. consent was obtained. Demographic information of each patient was noted. Urine was obtained and sam- ples were sent to the laboratory of the hospital and reports were assessed. If the value of albumin is raised in urine analysis (as per operational definition) then albuminuria was labeled. In patients who were diag- nosed as with albuminuria, total cholesterol was noted. If cholesterol was > 240 mg/dl, then hypercholestero- lemia was labeled by researcher himself. Conclusion: The results of the study conclude that frequency of microalbuminuria among patients of newly diagnosed type-2 diabetic mellitus is in agree- ment with other studies while the frequency of hyper- cholesterolemia in patients with microalbuminuria was also recorded higher which needs special physicians attention for its timely management so that patients can be prevented from severe cardio vascular morbidi- ties and mortality. Keywords: Diabetes Mellitus Type 2, microalbumi- nuria, hypercholesterolemia. Introduction Diabetes mellitus (DM) is the metabolic syndrome that takes away a lot of economic resources for the deve- loping world. 1 Globally, as of 2010, an estimated 285 million people had diabetes, with type 2 making up about 90% of the cases. 2 Diabetes Mellitus is on an alarming rise especially in the last two decades. 1 Acco- rding to a recent survey, this disease has affected aro- und 240 million people worldwide. 3 As far as disease burden in Pakistan is concerned, prevalence of newly diagnosed diabetes was 5.1% in men and 6.8% in women in urban areas. 4 Diabetic nephropathy or microalbuminuria is the leading cause of renal failure. Microalbuminuria is defined as albumin excretion of 30 – 299 mg/24 hours. Original Article Corresponding Author: Fawad Ahmad Randhawa Assistant Professor of Endocrinology, King Edward Medical University Email: fawad@kemu.edu.pk.