Turk J Vet Anim Sci 25 (2001) 287-294 © TÜB‹TAK 287 Deneysel Enfekte Beyaz Farelerde Strobilocercus fasciolaris’e Albendazol ve Praziquantel’in Etkisi Kader YILDIZ K›r›kkale Üniversitesi, Veteriner Fakültesi, Parazitoloji Anabilim Dal›, Kampüs, K›r›kkale - TÜRK‹YE Ahmet DO/ANAY Ankara Üniversitesi, Veteriner Fakültesi, Helmintoloji Bilim Dal›, Ankara - TÜRK‹YE Gelifl Tarihi: 05.11.1999 Özet: Bu çal›flma S. fasciolaris’in geliflimine ve sa¤alt›m›na albendazol ve praziquantel’in etkilerini incelemek için yap›lm›flt›r. ‹laçlar S. fasciolaris geliflimine koruyucu etkilerinin belirlenmesi amac›yla enfeksiyondan iki gün önce bafllanarak 30 gün süreyle, S. fasciolaris sa¤alt›m›na etkilerinin belirlenmesi için ise enfeksiyonun 63. gününden itibaren 14 gün süreyle uygulanm›flt›r. Albendazol 15 mg/kg (150 ppm), praziquantel 200 mg/kg (2000 ppm) dozda yemle birlikte verilmifltir. Albendazol’ün S. fasciolaris geliflimine koruyucu etkisinin belirlendi¤i grupta makroskobik olarak hiçbir kistin geliflmedi¤i saptanm›fl, ancak bu farelerin karaci¤erlerinin histolojik kesitlerinde küçük kistik yap›lara rastlanm›flt›r. Bu ilac›n geliflen S. fasciolaris’lere etkisinin denendi¤i gruptaki farelerdeki kistlerin tamam›na etkili oldu¤u belirlenmifltir. Praziquantel’in kist geliflimine koruyucu etkisinin denendi¤i gruptaki farelerde ilac›n kist geliflimine engel olmad›¤› fakat pozitif kontrol grubundakilere oranla karaci¤erde geliflen kist say›s›n› azaltt›¤› gözlenmifltir. Praziquantel’in geliflmekte olan S.fasciolaris’lere etkisi % 27.2 olarak saptanm›flt›r. Geliflen S.fasciolaris’lere etkisinin belirlenmesi için uygulanan gruptaki farelerdeki S.fasciolaris’lere etkisi % 93.4 oldu¤u tespit edilmifltir. Sonuçta albendazol’ün S. fasciolaris gelifliminde koruyucu etkisi oldu¤u gözlenirken praziquantel’de bu duruma rastlanmam›fl, geliflen kistlerin sa¤alt›m›nda her iki ilaç da baflar›l› olmufltur. Anahtar Sözcükler: Strobilocercus fasciolaris, fare, albendazol, praziquantel The Efffect of Albendazole and Praziquantel on Strobilocercus fasciolaris in Experimentally Infected Mice Abstract: This study was conducted to analyze the effects of albendazole and praziquantel on the development and treatment of S. fasciolaris. In order to determine the prophylactic effects on the development of S. fasciolaris, the drugs (albendazole and praziquantel) were given 2 days before the infection and for a period of 30 days. Also, to determine the effects of treatment, both drugs were given on the 63 rd day of the infection and for a period of 14 days. The dosages of albendazole and praziquantel were 15 mg/kg (150 ppm) and 200 mg/kg (2000 ppm) respectively. They were given with the normal daily diet. In the group in which albendazole had a prophylactive effect on the development of S. fasciolaris, no macroscopic cystic development was observed. However, in the histological sections of the livers, some microscopic cystic structures were found. In the group in which the effects of the drug were tested all the cysts were affected. In the group in which the prophylactic effects of praziquantel on cyst development were tested, it was observed that the drug had no effect on the development of cysts, but compared to the positive control group (no drugs given), the drug reduced the number of cysts in the liver. The effects of praziquantel on the developing S. fasciolaris were calculated to be 27.2% . The preventive effect of praziquantel on the developed S. fasciolaris was calculated to be 93.4%. As a result, while prophylactic effects of albendazole on the development of S. fasciolaris were observed, no such effects were observed with praziquantel. Both drugs were effective in the treatment of developing cysts. Key Words: Strobilocercus fasciolaris, mice, albendazole, praziquantel