Introduction Epilepsy is a central nervous system (CNS) malfunction that leads either to generalized hyperactivity involving essentially all parts of the brain or to hyperactivity of only a portion of the brain (Guyton, 1976). epilepsy is a collective term that includes over 40 different types of human seizures disorders. Approx 1% of the world population at any one time (>50 million people worldwide) is afflicted with these serious neurological disorders. Although the current drug provides adequate seizure control in many patients, it is roughly estimated that up to 28- 30% of patients are poorly treated with the available antiepileptic drugs (AEDs). Moreover, many (AEDs) have serious side effects and lifelong medication may be required. Conventional antiepileptic drugs (AEDs). Phenobarbital, primidone, phenytoin, carbamazepine, ethosuximide, and benzodiazepines, are widely used but exhibit an unfavorable side effect profile and failure to adequately control seizures in the recent year new drugs (Oxcarbazepine, Lamotrigine, Topiramate, Gabapentin, Zonisamide, Tiagabine, Fosphenytoin, Vigabatrine & felbamate) have been added to the list of therapeutic agents against epilepsy (Mccormick and Contreras, 2001). However, there is a significant group of patients (up to 30%) who are resistant to the available anti-epileptic drugs. The long-established AED control seizures in 50% of people developing partial seizures and in 60-70% of those developing generalized seizures (Meador, 2003). In the 1960s, research in antiepileptic drug development Screening of some Semicarbazones as anticonvulsant agent Ajay Kumar Garg *, Ranjan Kumar Singh , Khushboo Srimali , Saurabh K. Sinha 1 2 3 4 , Vivek Jain 4 1 Department of Pharmaceutical Chemistry, Shekhawati Institute of Pharmacy, Rajasthan, India 2 Department of Pharmacology, Shekhawati Institute of Pharmacy, Rajasthan, India 3 Department of Pharmaceutical Chemistry, Mahatma Gandhi College of Pharmacy, Rajasthan, India 4 Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan-313001, India * Corresponding Author: Address for Ajay Kumar Garg Department of Pharmaceutical Chemistry, Shekhawati Institute of Pharmacy, Rajasthan, India Email: ajay.pharma3006@gmail.com Abstract Objective: The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. In this project, the synthesis of semicarbazone derivatives was Matearial and Methods: carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semicarbazide, which was directly coupled with ketones. All the synthesized compounds were biologically screened for their anticonvulsant activity by the MES method. Results: Standard error mean was calculated concerning standard and control drug, Phenytoin sodium (25mg/kg.) and DMSO. The synthesized semicarbazone was characterized by using IR Spectroscopy. One another representative molecule compound was characterized using H NMR Spectroscopy. It can be concluded that designed 1 Conclusion: semicarbazones were synthesized and characterized successfully. After synthesis of designed semicarbazones compounds were evaluated for anticonvulsant activity. Finally, two compounds have shown better activity in comparison to the other molecules. Keywords: Semicarbazone, MES, SEM, anticonvulsant activity, IR, NMR spectroscopy Research Article Received: 17 January 2022 Revised: 7 February 2022 Accepted: 26 February 2022 www.apjonline.in DOI: https://doi.org/10.31024/apj.2022.7.1.2 2456-1436/Copyright © 2022, N.S. Memorial Scientific Research and Education Society. This is an open access article under the CC BY- NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Advance Pharmaceutical Journal 2022; 7(1):16-22 16