Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cbdd.13075 This article is protected by copyright. All rights reserved. PROFESSOR FERNANDA BORGES (Orcid ID : 0000-0003-1050-2402) Article type : Research Article Coumarins and adenosine receptors: new perceptions in structure-affinity relationships André Fonseca a, b , Maria João Matos* a , Santiago Vilar a,b , Sonja Kachler c , Karl-Norbert Klotz c , Eugenio Uriarte b, d and Fernanda Borges* a a CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169- 007, Porto, Portugal b Departamento Quimica Orgánica, Facultade de Farmacia, Universidad Santiago de Compostela, 15782, Santiago de Compostela, Spain c Pharmacology and Toxicology Institute, University of Würzburg, 97078, Würzburg, Germany d Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, 7500912, Santiago de Chile, Chile. *Corresponding Authors: Fernanda Borges, CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal. E-mail: fborges@fc.up.pt Maria João Matos, Organic Chemistry Department, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.Email: mariacmatos@gmail.com Keywords: Coumarins; Adenosine Receptors; Carboxamidocoumarin;