Materials Sciences and Applications, 2022, 13, 532-557 https://www.scirp.org/journal/msa ISSN Online: 2153-1188 ISSN Print: 2153-117X DOI: 10.4236/msa.2022.1310033 Oct. 31, 2022 532 Materials Sciences and Applications Synthesis and Physicochemical Studies for Novel Bioactive Metal Complexes of Macrolide Antibiotic Tylosin Alaa E. Ali 1 , Gehan S. Elasala 1 , Yasser S. Mahrous 1 , Mohamed H. Sharaf 2 , Ismael M. Elkamhawy 1* 1 Chemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt 2 Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt Abstract Tylosin is a well-established antibiotic that has been widely employed in hu- man and veterinary medicines. It can act as a potential ligand binding metal ions due to various donor atoms in the structure. Our study on the complexa- tion of various metal ions with tylosin ligand revealed that they preferably coordinate with mycaminose fragment to establish Novel trends complexes. Tylosin ligand (TYS) behaves as bidentate for complexation with different metal ions such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II). Various essential metal complexes of tylosin were synthesized and characte- rized by techniques such as UV, IR, Elemental analysis, magnetic susceptibil- ity and ESR spectra of Cu(II) complex. These techniques are used to know their geometries and mode of bonding, with stoichiometry, 2:2 (M:L). Ther- mal analysis (TGA and DTA) of ligands and their metal complexes were car- ried out to distinguish between the coordinate and hydrate solvents and to es- timate the stability ranges, peak temperatures. The thermodynamic parameters, such as activation energy (ΔE*), the enthalpy of activation (ΔH*), entropy of ac- tivation (ΔS*) and Gibbs free energy (ΔG*) are calculated and discussed. Some tylosin complexes show higher activity than tylosin for some bacterial and fungal strains. Low concentration value of minimum inhibitory concentration (MIC) results is 15.625 µg/ml for both complexes [Zn 2 (TYS) 2 Cl 2 (H 2 O) 4 ]·25H 2 O and [Cu 2 (TYS) 2 Cl 2 (H 2 O) 4 ]·25H 2 O with B. cereus genus maybe a valuable data used to produce novel therapeutic agent. This study constitutes several essen- tial aspects for future research on tylosin metal complexes as antibacterial as- sessment and as potential medicinal agents. Keywords Tylosin Complexes, Synthesis, Spectral, Tetragonal Distortion, How to cite this paper: Ali, A.E., Elasala, G.S., Mahrous, Y.S., Sharaf, M.H. and El- kamhawy, I.M. (2022) Synthesis and Phy- sicochemical Studies for Novel Bioactive Metal Complexes of Macrolide Antibiotic Tylosin. Materials Sciences and Applica- tions, 13, 532-557. https://doi.org/10.4236/msa.2022.1310033 Received: August 3, 2022 Accepted: October 28, 2022 Published: October 31, 2022 Copyright © 2022 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access