1 Extended in vitro inactivation of SARS-CoV-2 by titanium dioxide surface coating Mlcochova, P 1 , Chadha, A 2 , Hesselhoj, T 3,4 , Fraternali, F 4,5 , Ramsden, JJ 6 , Gupta, RK 1,2* 1 Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK 2 Cambridge Universities Hospitals NHS Trust, Cambridge, UK 3 Invisismart Technologies, UK 4 Randall Centre for Cell and Molecular Biophysics, King’s College London, London, SE1 1UL, UK 5 Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, London NW1 1AT, UK 6 Clore Laboratory, University of Buckingham, Buckingham, UK *Correspondence Ravindra K. Gupta Cambridge Institute for Therapeutic Immunology and Infectious Diseases Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus Puddicombe Way Cambridge CB2 0AW Email: Rkg20@cam.ac.uk Abstract SARS-CoV-2 transmission occurs via airborne droplets and surface contamination. We show tiles coated with TiO 2 120 days previously can inactivate SARS-CoV-2 under ambient indoor lighting with 87% reduction in titres at 1h and complete loss by 5h exposure. TiO 2 coatings could be an important tool in containing SARS-CoV-2. . CC-BY-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted December 8, 2020. ; https://doi.org/10.1101/2020.12.08.415018 doi: bioRxiv preprint