22nd World Congress on Ultrasound in Obstetrics and Gynecology Poster abstracts Results: For renal volumes, a high correlation between 2 and 3D measurements, and between 3D measurements on the left and right side was observed. Bladder volume assessment correlated well between the sono AVC and VOCAL technique. Urine production gradually increased with gestational age with a large interfetal difference late in gestation. Fetal venous and arterial doppler flow measurements in the left and right kidney did not differ significantly; the PSV increases gradually with gestational age. The PI for renal veins remains almost constant. There was a good correlation between renal volume, fetal urine production and PSV of the renal artery. Conclusions: Reference curves for renal volume, fetal urine production and renal Dopplers flow measurements in normal pregnancies are provided. These will serve as potential predictors for renal function in fetuses with renal and urinary tract pathology. P16.14 The association between ischemia-modified albumin levels in umbilical vein and intrauterine growth restriction O. Karadeniz 1 , I. Mendilcioglu 1 , S. Ozdem 2 , M. Ozekinci 1 , C. Y. Sanhal 1 , G. Uzun 2 , M. Sakinci 1 , M. Simsek 1 1 Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey; 2 Biochemistry, Akdeniz University, Antalya, Turkey Objectives: Ischemia-modified albumin (IMA) was used for the first time as an early marker of ischemia in acute coronary syndrome. When tissue ischemia occurs, circulating albumin is exposed to structural changes. As a result of this change, cobalt binding characteristic of albumin decreases and they can not bind each other. In this study, we aimed to determine whether IMA can be used in the diagnosis of intrauterine growth restriction (IUGR). Methods: We performed a prospective study including 40 patients with IUGR and 40 with normal fetal development. Fetuses were diagnosed as IUGR if estimated fetal weight (EFW) < 10 th percentile in ultrasound. All the cases were followed in the Department of Obstetrics & Gynecology, Akdeniz University Faculty of Medicine, between 2010 February and November 2010. Blood samples were obtained from the umbilical vein after delivery to detect IMA levels and pH. Results of the two groups were compared statistically. Results: Ages were similar between IUGR and control groups (27.8 ± 6.03 vs. 28.5 ± 5.91, respectively, P = 0.602). Gestational age at delivery was lower in IUGR group than control group (36.4 ± 2.89 vs. 37.8 ± 2.24, respectively, P = 0.018). IMA levels in the IUGR group were statistically significantly higher than the control group (78.74 ± 6.87 vs. 74.43 ± 7.84 U/ml, respectively, P = 0.011). No significant difference was detected in terms of pH values of umbilical vein between those two groups (7.32 ± 0.04 vs. 7.33 ± 0.04, respectively, P = 0.342). Conclusions: We can suggest that IMA can be a valuable marker for IUGR. Thus, pregnant women accompanying any risk of IUGR can be diagnosed by measuring IMA levels in the umbilical vein before and after delivery. P16.15 Subsequent pregnancy outcomes in women with prior pregnancy complicated by both very low birth weight and small for gestational age infant M. Matsushita , T. Murakoshi, S. Nakayama Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan Objectives: To assess the subsequent pregnancy outcomes in women with prior pregnancy complicated by both very low birth weight (VLBW) and small for gestational age (SGA) infant. Methods: Prior pregnacy was complicated by VLBW and SGA infant with singleton pregnancy, normal anatomy and normal fetal karyotype. VLBW and SGA infant was defined as birth weight below 1000 g and as below 10 th percentlile according to local standards. Subseqent pregnancy outcome was defined as still birth, neonatal death, extremely low birth weight (ELBW), VLBW, low birth weight (LBW), very preterm birth (VPB), preterm birth(PB), and SGA. Uterine arterial Doppler was recorded in both prior and subsequent pregnancy. Results: There were 21 cases matched with study protocol. In prior pregnancy, 10 cases were complicated by pre-eclampsia and 4 neonates were resulted in neonatal or infantile death. In all cases, uterine arterial doppler showed elevated pulsality index (PI). In subsequent pregnancy, there were 2 still births. 0 neontal deaths, 4 ELBW infants, 5 VPB infants and 11 SGA infants. Nine of 11 cases with elevated uterine arterial PI at mid trimester were resulted in SGA infant. Conclusions: In subsequent pregnancy, birth weight and gestational week were higher than in prior pregnancy. Meanwhile, two of 21 pregnancies were resulted in still birth, ELBWI and VPB. Reccurrent risk of SGA in subsequent pregnancy was 52%. P16.16 Fetal growth restriction: obstetrics and neonatal outcomes A. P. Zamarian, A. R. Caetano, R. Cavalcante, L. Nardozza, A. R. Hatanaka , E. Araujo, A. F. Moron Obstetrics, UNIFESP-EPM, S ˜ ao Paulo, Brazil Objectives: Our purpose was to analyze the obstetric and neonatal outcomes of the pregnancies complicated by fetal growth restriction (FGR) in Sao Paulo Federal University. Methods: This is a descriptive study based on patients records review. All charts of pregnant women in the sector of fetal growth restriction who delivered at UNIFESP in the year of 2011 were reviewed. All fetuses with prenatal diagnosis of FGR, fetal weight estimated by ultrasound below the 10 th percentile for gestational age and with normal umbilical Doppler, were included. We shared the restricted fetuses into 2 groups: estimated weight < P3 (group A) and estimated weight between the P3 and P10 (group B). We analyzed data on gestacional age and type of delivery, apgar score, umbilical cord pH and length of stay in neonatal intensive care unit. Results: During this period there had been delivered 20 growth restricted fetus, 10 in group A and 10 in group B. The average gestational age of delivery was 36 weeks (34–39) in group A versus 37 weeks (29 – 41) in group B. Group B had an extremely premature newborn, 29 weeks, due placental abruption. Type of delivery: 80% of Cesarean section in group A (30% due to acute fetal distress) versus 70% in group B (50% because of other obstetrics indications like repeated Cesarean and breech presentation). We do not had any 5 minute Apgar score below 7 and no cord pH below 7.05. The main difference between the two groups was the length of neonatal intensive care admission, 17 days (0–93) in group A versus 9 days (0–45) in group B. No neonatal deaths occurred. Conclusions: Fetal growth restriction affects 5 to 10% of pregnancies and is the second primary cause of perinatal mortality with more incidence of premature delivery, fetal distress and admission in neonatal intensive care unit. Our data demonstrate that, even in cases with normal umbilical artery Doppler and no acidosis, restricted fetus, especially those < P3, have a higher morbidity, staying for longer periods in intensive care units. P16.17 Early embryonic heart rate and pregnancy outcome K. Szili 1 , E. Ferencz 1 , A. Szab ´ o 1 , J. Szab ´ o 2 , J. Sikovanyecz 2 , J. Szab ´ o 1 1 Department of Medical Genetics, University of Szeged, Szeged, Hungary; 2 Obstetrics and Gynecology Department, University of Szeged, Szeged, Hungary Objectives: Early prediction of pregnancy outcome is important either from the medical or from the patient’s point of view. The 234 Ultrasound in Obstetrics & Gynecology 2012; 40 (Suppl. 1): 171–310