Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Medicine and Health Journal homepage: https://journal.uii.ac.id/JKKI ABSTRACT ARTICLE INFO The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus Tri Agusti Sholikah* 1 , Sri Wulandari 2 , Indah Ariesta 3 , Muhammad Arif Rakhman Hakim 3 , Muhammad Hafizhan 3 1 Department of Histology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 2 Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 3 Undergraduate student, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia *Corresponding author: agusti3.dr@gmail.com Keywords: Elephantopus scaber L, flavanoid, DM rat model History: Received: July 17, 2019 Accepted: July 27, 2020 Online: August 31, 2020 DOI: 10.20885/JKKI.Vol11.Iss2.art10 Original Article Copyright @2020 Authors. This is an open access article distributed under the terms of the Creative Commons At- tribution-NonCommercial 4.0 International Licence (http:// creativecommons.org/licences/ by-nc/4.0/). 172 Background: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality. The pathogenesis of DM involves pancreatic β-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids are antioxidants that play a role in reducing pancreatic β-cell damage or damage to other tissues, which potentially reduce blood glucose levels. Objective: To determine the hypoglycemic effects of tapak liman using the DM rat models. Methods: Twenty-eight Wistar albino rats (Rattus novergicus) were divided into four groups: the normal control group (KKn), not induced by streptozotocin-nicotinamide (STZ-NA) intraperitoneal; negative control group (KK-), induced by STZ-NA; treatment group 1 (KP1), induced by STZ-NA and 150 mg/kg body weight of tapak liman plant extract; and the treatment group 2 (KP2), induced by STZ-NA and 300 mg/kg body weight of tapak liman. Blood glucose levels were measured on the 7th day after STZ-NA induction and the 28th day after the administration of tapak liman plant extract. The results were analyzed for statistical significance. Results: There was a significant decrease in blood glucose levels in KP1 and KP2 (p≤ 0.05). The decrease in blood glucose in KP1 had not reached normal levels compared to KP2. Conclusion: Administration of tapak liman plant extract at a dose of 300 mg/kg body weight in DM rat models reduced blood glucose levels to normal. Latar Belakang: Diabetes melitus (DM) merupakan salah satu penyakit dengan morbiditas dan mortalitas yang cukup tinggi. Patogenesis DM ditandai dengan kerusakan sel β pankreas atau gangguan sensivitas insulin yang menyebabkan naiknya kadar glukosa darah. Tanaman herbal tapak liman (Elephantopus scaber L) diketahui mempunyai kandungan flavonoid yang cukup tinggi. Flavonoid berfungsi sebagai antioksidan untuk mengurangi kerusakan sel β pankreas ataupun jaringan lainnya sehingga berpotensi menurunkan kadar glukosa darah. Tujuan: Penelitian ini bertujuan untuk untuk mengetahui apakah pemberian ekstrak tanaman tapak liman dapat menurunkan kadar glukosa darah puasa tikus putih model DM. Metode: Sampel sebanyak 28 ekor tikus putih (Rattus novergicus) dibagi menjadi 4 kelompok yaitu kelompok kontrol normal (KKn) yang tidak diinduksi streptozotosin-nikotinamid (STZ-NA) intraperitoneal; kelompok kontrol negatif (KK-) yang diinduksi STZ-NA; kelompok perlakuan 1 (KP1) diinduksi STZ-NA dan