_____________________________________________________________________________________________________ *Corresponding author: E-mail: eltrinitydrugs@yahoo.com, samueloffor@uniuyo.edu.ng; Journal of Complementary and Alternative Medical Research 17(1): 37-45, 2022; Article no.JOCAMR.82679 ISSN: 2456-6276 Ameliorating Effects of Solanum anomalum Thonn. Ex. Schumach Fruit Extracts on Paracetamol- induced Kidney Injuries and Haemato-biochemical Indices in Rats Samuel J. Offor a* , Sifon Obong J. Akpan a , Adedayo A. Tologbonse a , Romanus A. Umoh b and Daniel F. Akpan a a Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria. b Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JOCAMR/2022/v17i130325 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/82679 Received 12 November 2021 Accepted 16 January 2022 Published 17 January 2022 ABSTRACT Paracetamol (acetaminophen) is a widely used non-opioid analgesic and antipyretic drug that is safe at therapeutic doses but toxic to the liver and kidneys in overdose. Although the risk of paracetamol-induced liver injury is much higher than in the kidneys, incidents of kidney damage by paracetamol should not be ignored, given the enormous cost of treating kidney diseases, particularly in resource-challenged developing nations. In an onerous quest for a cheaper and readily available antidote, this study examined the effect of Solanum anomalum fruit extract on paracetamol-induced kidney injuries and haemato-biochemical indices in rats. Twenty-five mature albino rats of both sexes were used, divided into five groups of five rats per group. Group 1 (normal control) rats were given distilled water (10ml/kg) for 8 days, group 2 (negative control) given distilled water (10 ml/kg) for 8 days, group 3 (positive control) given 100 mg/kg Silymarin for 8 days, group 4 given 452 mg/kg of S. anomalum fruit extract for 8 days, and group 5 given 678 Original Research Article