This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/LAM.13265 This article is protected by copyright. All rights reserved DR. KUSUMAWADEE UTISPAN (Orcid ID : 0000-0002-3825-3922) Article type : LAM - Original Article A novel non-cytotoxic synthetic peptide, Pug-1, exhibited an antibiofilm effect on Streptococcus mutans adhesion Paopanga Kokilakanit 1 , Sittichai Koontongkaew 1,2,3 , Sittiruk Roytrakul 4 , Kusumawadee Utispan 1,2 1 Oral Biology Research Unit, Faculty of Dentistry, Thammasat University (Rangsit campus), Pathum Thani, Thailand 2 Center of Excellence in Medicinal Herbs for Treatment of Oral Diseases, Thammasat University, Thailand 3 Walailak University International College of Dentistry, Walailak University, Bangkok, Thailand. 4 Genome Institute, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand Running headline: Non-cytotoxicity and antibiofilm activity of Pug-1 Corresponding author Kusumawadee Utispan Faculty of Dentistry, Thammasat University (Rangsit campus), Pathum Thani, 12121, Thailand. Tel: +662-986-9213 Accepted Article