Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization Marina Costa, a) Romane Josselin, a) Diana F. Silva, b) Sandra M. Cardoso, b),c) Nóra V. May, d) Sílvia Chaves, a)* M. Amélia Santos a)* a) Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av, Rovisco Pais 1, 1049-001, Lisboa, Portugal b) CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal c) Institute of Molecular and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal d) Research Centre for Natural Sciences, 1117 Magyar tudósok körútja 2 Budapest, Hungary Keywords: Hydroxyphenyl-benzimidazole; Donepezil; Anti-neurodegeneratives; Alzheimer´s disease; Multifunctional drugs; Metal chelation. * Corresponding authors: (Sílvia Chaves) E-mail: silvia.chaves@tecnico.ulisboa.pt; Phone: +351-218419269 (M. Amélia Santos) E-mail: masantos@tecnico.ulisboa.pt; Phone: +351-218419273