_____________________________________________________________________________________________________ *Corresponding author: E-mail: muchyscki@gmail.com; Journal of Advances in Microbiology 22(9): 77-84, 2022; Article no.JAMB.87946 ISSN: 2456-7116 Thyroid Hormones and Red Cell Indices of HIV Subjects at Enugu Ngwu Amauche Martina a* , Ugwu Ifeanyichukwu Basil a , Ene Afoma a and Okolo Raphael Chinweike b a Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Enugu State University of Science and Technology, Enugu, Nigeria. b School of Medical Laboratory Technician, Bishop Shanahan Hospital Nsukka Enugu State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author NAM designed the study, wrote the protocol and wrote the first draft of the manuscript, performed the statistical analysis and managed the analyses of the study. Author EA managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMB/2022/v22i930490 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/87946 Received 05 April 2022 Accepted 10 June 2022 Published 04 July 2022 ABSTRACT Background: Thyroid hormones act on nearly every cell in the body including red blood cells. Thyroid hormones are also important to proper development and differentiation of all cells of the human body. Human Immunodeficiency Virus (HIV) is a virus that destroys certain cells in the immune system. The aim of this study was to determine free triiodothyronine (FT3), free thyroxine (T4) and red cell indices level of HIV subjects attending clinic at Enugu State University of Science and Technology Teaching Hospital. Study Design: Case control study. Place and Duration of Study: Human Immunodeficiency Virus (HIV) clinic and Haematology Laboratory both of Enugu State University of Science and Technology Teaching Hospital, between August and October 2021. Methodology: Sixty HIV subjects and thirty apparently healthy individuals within the age range of 30 - 60 years were recruited for this study. Free triiodothyronine (FT3), free thyroxine (FT4), hemoglobin (HGB), packed cell volume (PCV), red blood cell count (RBC), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), red cell Original Research Article