The Isoxazole Ring and Its N-Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics George N. Pairas, [a] Fereniki Perperopoulou, [b] Petros G. Tsoungas,* [c] and George Varvounis [d] Dedicated to Dr. A. J. Boulton with respect and friendship. ChemMedChem 2017, 12, 1 – 13 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 1 & These are not the final page numbers! ÞÞ These are not the final page numbers! ÞÞ Reviews DOI: 10.1002/cmdc.201700023