Medtronic-CoreValve Ò device was utilized in 195 (71%) and the Edwards-Sapien Ò device in 80 (29%) of patients. The trans-femoral, trans-axillar, trans-apical, trans- aortic and retroperitoneal route were used in 224, 20, 29, 1 and 1 patients; respec- tively. Procedural success was 97.1%. One month, 1 year, 2 and 3 years survival rates were 97%, 91%, 85% and 70%; respectively. Two patients (0.7%) needed urgent car- diac surgery due to pericardial tamponade. Peri-procedural\in-hospital stroke was diagnosed in 9 (3.2%) patients. Permanent pacemaker was required in 40 (14.5%) patients: (36 cases in CoreValve and 4 in Sapien valves). Significant paravalvular leak (moderate) was noted in 22 (8%) patients. After the procedure, mean valve gradients decreased from 51.216 to 8.17 (p<0.001). Symptomatic improvement was evident during follow up, having 98% of patients in NYHA-FC I or II. CONCLUSION The current report signifies that catheter-based treatment of mostly elderly patients with severe aortic stenosis is feasible, safe and associated with satisfactory long-term outcomes. This approach has proved itself in ’real life’ of TAVI practice as shown by the reported results. CRT-806 Impact of Body Mass Index on Outcomes of Severe Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement Edward Koifman, Sarkis Kiramijyan, Marco Magalhaes, Sa’ar Minha, Smita Negi, Ricardo Orlando Escarcega, Sandeep Kumar, Zack D. Jerusalem, Nevin C. Baker, Itsik Ben-Dor, Christian Shults, Paul J. Corso, Lowell Satlet, Augusto Pichard, Rebecca Torguson, Ron Waksman MedStar Washington Hospital Center, Washington, DC BACKGROUND Obese aortic stenosis patients undergoing surgical replacement have improved survival in comparison with underweight patients. Currently there are scarce data regarding BMI impact on outcome of severe aortic stenosis patients un- dergoing transcatheter aortic valve replacement (TAVR). OBJECTIVE Our aim was to assess the impact of BMI on mortality and complications rate of TAVR patients. METHODS Patient population included all severe AS patients undergoing TAVR at our institution, between May 2007 and July 2014. Baseline demographic, clinical and imaging parameters were compared between 3 patients groups according to BMI (<20, 20-30 and >30), peri-procedural complications rate were assessed and mortality was evaluated by the BMI group. RESULTS Among 340 severe AS patients undergoing TAVR, 9% (n¼29) were under- weight with a BMI<20, 64% (n¼219) had a BMI of 20-30, and 27% (n¼29) were obese with BMI >30. Patients with BMI 20-30 were older and had higher proportion of men in compar- ison with under- and overweight patients (857 vs. 8118 and 808, p<0.001 and 61 vs. 28 and 35%, p<0.001). Diabetes Mellitus was more prevalent as BMI increased, while the STS score was inversely related to BMI (125%, 94% and 94%, for the underweight, normal weight and obese respectively, p¼0.004). Survival comparison has showed increased mortality rates among underweight patients, but no significant difference was noted between the normal and obese patients (graph). CONCLUSION Underweight severe aortic stenosis patients undergoing TAVR have increased risk for long term mortality in comparison with normal weight or obese patients, however obesity doesn’t seem to portend significantly higher survival rates when compared with normal weight TAVR patients. CRT-807 Prognostic Impact of Improvement in Intra-Operative Pulmonary Artery Systolic Pressure and Left Ventricular Ejection Fraction in Patients Undergoing Trans- Catheter Aortic Valve Replacement Atish P. Mathur, Yulanka Castro, Hayder Hashim, Ahmed Abdel-Razek, Pranaychandra Vaidya, Thomas Cocke, Paul Andrews, Jock McCullough, Elie Elmann, Gabriele DiLuozzo, Joseph Parrillo Hackensack University Medical Center, Hackensack, NJ BACKGROUND Previous studies have demonstrated reduced survival in high risk patients with symptomatic AS undergoing TAVR who had elevated pulmonary artery systolic pressure (PASP) at baseline. However, effects of elevated intra-operative PASP on long term outcomes in these patients are not clearly defined. METHODS We retrospectively evaluated 100 consecutive patients undergoing TAVR at our institution between 2012 and 2013. Baseline characteristics, 30 day major adverse cardiovascular events (MACE), defined as composite end point of stroke, myocardial infarction, cardiovascular death or re-hospitalization, and 1 year all-cause mortality stratified by intra-operative PASP were analyzed. RESULTS On cox regression survival analysis in patients undergoing TAVR, being in the highest tertile of intra-operative PASP was an independent predictor of a higher 30 day MACE event rate (HR: 4.1, 95% CI: 1.8 to 9.2, p ¼ 0.001) and long term mortality at 12 month (hazard ratio (HR): 6.6, 95% confidence interval (CI): 3.8 to 11.4, p < 0.001). Following TAVR, patients with greater than 10mmHg reduction in their intra-operative PASP, had improved long term survival at 12 months (HR: 0.14, 95% CI: 0.04 to 0.46, p ¼ 0.001). In addition, an increase of greater than 5% in left ventricular (LV) ejection fraction (EF) after TAVR was also associated with improved long-term survival at 12 months (HR: 0.23, 95% CI: 0.07 to 0.78, p ¼ 0.02). CONCLUSION In high risk patients with severe aortic stenosis, elevated pulmonary artery systolic pressures during trans-catheter aortic valve replacement was associ- ated with reduced survival at 1 year. Reduction in PASP after TAVR was one of the strongest predictor of survival in our patient population. More large scale randomized studies are needed to further evaluate these results. S50 JACC: CARDIOVASCULAR INTERVENTIONS, VOL. 8, NO. 2, SUPPL S, 2015 VALVE & STRUCTURAL HEART brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by Elsevier - Publisher Connector